Evidence map›Paper›PMID 40763738›Full record

ArticleCell reports. Medicine2025

Lassa fever in African green monkeys: Clinical disease and fatal outcome are associated with systemic viral dissemination and inflammation.

Robert W Cross, Abhishek N Prasad, Jacquelyn Turcinovic, Viktoriya Borisevich, Krystle N Agans, Courtney Woolsey, Daniel J Deer, Mack B Harrison, Rachel O'Toole, Alejandro Villasante-Tezanos and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Robert W CrossGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Abhishek N PrasadGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Jacquelyn TurcinovicGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Viktoriya BorisevichGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Krystle N AgansGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Courtney WoolseyGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Daniel J DeerGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Mack B HarrisonGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Rachel O'TooleGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Alejandro Villasante-TezanosDepartment of Biostatistics and Data Science, University of Texas Medical Branch, Galveston, TX, USA.
Joseline Velasquez-ReyesDepartment of Virology, Immunology & Microbiology, Chobanian and Avedisian School of Medicine, Boston University, Boston, MA 02215, USA; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02215, USA.
Natalie S DobiasGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
John H ConnorDepartment of Virology, Immunology & Microbiology, Chobanian and Avedisian School of Medicine, Boston University, Boston, MA 02215, USA; National Emerging Infectious Diseases Laboratories, Boston University, Boston, MA 02215, USA.
Karla A FentonGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA.
Thomas W GeisbertGalveston National Laboratory, University of Texas Medical Branch, Galveston, TX, USA; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, USA. Electronic address: twgeisbe@utmb.edu.

Funding

Regulatory Compliance Core - Galveston National Laboratory BSL4 OperationsUC7AI094660 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI Thomas Gary Ksiazek · 2011 to 2026
$208.8M
NIAID NIH HHS UC7 AI094660
6 · The paper itself

Abstract

Lassa virus (LASV) causes significant human morbidity and mortality in endemic areas of West Africa. Previous studies have shown that cynomolgus macaques of non-Mauritius Asian origin best reproduce clinical features of human Lassa fever (LF). Because of the shortage of macaques caused by the COVID-19 pandemic, research on high-consequence pathogens including LASV has been severely hindered. We assessed the pathogenic potential of LASV in Mauritius-origin cynomolgus macaques (MCMs) and African green monkeys (AGMs) to find a more available alternative species to model LF. Importantly, we show similarity in transcriptomic host responses related to interferon signaling, cytokinemia, and immune cell dysregulation; however, AGMs more consistently reproduced hallmark features of LF, developing hemorrhagic manifestations closer to those seen in humans. We further show that the lethal dose 50 (LD

Indexed as

InflammationLassa FeverLassa virusAnimalsChlorocebus aethiopsCOVID-19Disease Models, AnimalFemaleHumansMacaca fascicularisMaleAfrican green monkeyanimal modelArenavirushemorrhagic feverhost responsesintranasalLassa virusmucosalnonhuman primatetargeted transcriptomics

Identifiers

PMID40763738
PMCPMC12432369

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.