ArticleCell host & microbe2025
Amino acid competition shapes Acinetobacter baumannii gut carriage.
Article in Cell host & microbe, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- ISmLife · 2026Article
- A regulator of amino acid catabolism controls Acinetobacter baumannii gut colonization.Nature communications · 2026Article
- Microbial interactions as key players shaping the emergence and spread ofMicrobiology (Reading, England) · 2026Review
- Sorbose metabolism promotes fitness and virulence inmSphere · 2026Article
- Article
- Phenotype-Guided Nanotherapeutic Strategies for Carbapenem-ResistantPharmaceutics · 2026Review
- Engineered gut symbionts mediate cross-phylum antagonism to suppress uropathogenicbioRxiv : the preprint server for biology · 2026Article
- Catabolism of serine enantiomers represses enterohemorrhagicProceedings of the National Academy of Sciences of the United States of America · 2026Article
- A regulator of amino acid catabolism controlsbioRxiv : the preprint server for biology · 2025Article
- Arginine utilization inInfection and immunity · 2025Article
- Harnessing the human gut microbiota: an emerging frontier in combatting multidrug-resistant bacteria.Frontiers in immunology · 2025Review
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Abstract
Asymptomatic colonization is often critical for persistence of antimicrobial-resistant pathogens, such as Acinetobacter baumannii, and can increase the risk of clinical infections. However, the ecological factors shaping A. baumannii gut colonization remain unclear. We show that A. baumannii and other pathogenic Acinetobacter evolved to utilize the amino acid ornithine, a non-preferred carbon source, to compete with resident microbiota and persist in the gut in mice. A. baumannii encodes ornithine succinyltransferase (AstO) necessary for catabolizing ornithine, especially in conditions of increased microbial diversity. Supplemental dietary ornithine promotes long-term fecal shedding of A. baumannii. By contrast, supplementation of preferred carbon sources-monosodium glutamate or histidine-abolishes the requirement for ornithine catabolism. Additionally, A. baumannii gut carriage is higher in formula-fed human infants, who generally consume higher levels of protein, revealing dietary impacts on Acinetobacter colonization. Together, these results reveal that ornithine catabolism facilitates A. baumannii colonization, providing a reservoir for pathogen spread.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.