Evidence map›Paper›PMID 40763586›Full record

Trial reportDrug and alcohol dependence2025

Understanding risk and protective factors associated with opioid misuse among at-risk adolescents and young adults in the emergency department.

Erin E Bonar, Meredith Kotov, Carrie Bourque, Patrick M Carter, Sarah J Clark, David W Hutton, Kelley M Kidwell, Cheryl A King, Eve D Losman, Sean Esteban McCabe and 2 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Drug and alcohol dependence, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Erin E BonarAddiction Center, Department of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA; Michigan Innovations in Addiction Care through Research & Education Program, Department of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA; Injury Prevention Center, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 10, Ann Arbor, MI 48109, USA. Electronic address: erinbona@med.umich.edu.
Meredith KotovAddiction Center, Department of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA.
Carrie BourqueAddiction Center, Department of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA.
Patrick M CarterInjury Prevention Center, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 10, Ann Arbor, MI 48109, USA; Department of Emergency Medicine, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd Building 10-G080, Ann Arbor, MI 48109, USA; Department of Health Behavior and Health Education, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, USA.
Sarah J ClarkDepartment of Pediatrics, University of Michigan, 300 North Ingalls, Ann Arbor, MI 48109, United States.
David W HuttonDepartment of Health Management and Policy, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, USA.
Kelley M KidwellDepartment of Biostatistics, School of Public Health, University of Michigan, 1415 Washington Heights, Ann Arbor, MI 48109, USA.
Cheryl A KingDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 4250 Plymouth Rd, Ann Arbor, MI 48109, USA.
Eve D LosmanInjury Prevention Center, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 10, Ann Arbor, MI 48109, USA; Department of Emergency Medicine, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd Building 10-G080, Ann Arbor, MI 48109, USA.
Sean Esteban McCabeCenter for the Study of Drugs, Alcohol, Smoking, and Health, School of Nursing, University of Michigan, 400 North Ingalls, Ann Arbor, MI 48109, United States.
Kai ZhengDepartment of Psychiatry, University of Michigan, North Campus Research Complex, 4250 Plymouth Rd, Ann Arbor, MI 48109, USA; Department of Informatics, Donald Bren School of Information and Computer Sciences, University of California, Irvine, Donald Bren Hall, Irvine, CA 92697, USA.
Maureen WaltonAddiction Center, Department of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA; Michigan Innovations in Addiction Care through Research & Education Program, Department of Psychiatry, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 16, Ann Arbor, MI 48109, USA; Injury Prevention Center, University of Michigan, North Campus Research Complex, 2800 Plymouth Rd. Building 10, Ann Arbor, MI 48109, USA.

Funding

Optimized Interventions to Prevent Opioid Use Disorder among Adolescents and Young Adults in the Emergency DepartmentUH3DA050173 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BONAR, ERIN E., WALTON, MAUREEN A · 2020 to 2021
$5.8M
Optimized Interventions to Prevent Opioid Use Disorder among Adolescents and Young Adults in the Emergency DepartmentUG3DA050173 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BONAR, ERIN E., WALTON, MAUREEN A · 2019 to 2019
$699k
NIDA NIH HHS UG3 DA050173NIDA NIH HHS UH3 DA050173
6 · The paper itself

Abstract

backgroundOpioid misuse/opioid use disorder prevention strategies tailored for risk and protective factors are needed among adolescents and young adults (AYAs). We describe baseline risk/protective factors related to opioid misuse among at-risk AYAs who attended Emergency Departments (EDs) enrolled in a randomized controlled trial.

methodsPeople who recently visited an ED (ages 16-30) and self-reported 1) past-year prescription opioid use+a risk factor for misuse (i.e., drug use, binge drinking, depression symptoms, suicide risk) or 2) heroin or prescription opioid misuse at screening were enrolled. Measures assessed background characteristics and risk/protective factors. Analyses compared participants based on whether they reported opioid misuse or were at-risk for misuse.

resultsWe enrolled 1155 people (27.5 % male); 79.5 % reported opioid use+risk factor and 20.5 % reported opioid misuse. In unadjusted analyses, relative to those with opioid use+risk factor, those with opioid misuse were significantly more likely to report: male sex, Black/African American race, receiving public assistance, food insecurity, stronger opioid use motives, greater substance use, a prior suicide attempt, violence involvement, and greater impulsivity. They also reported lower social support, prosocial activities, and self-efficacy to avoid substances. In adjusted analyses, those with opioid misuse were significantly more likely to be male, have greater alcohol and other substance use, and report violence, with lower self-efficacy and social support. DISCUSSION: Social determinants of health, other substance use, social support, self-efficacy, etc., were key factors differentiating AYAs who have misused opioids from those at-risk for future misuse. Prevention and early interventions may be improved via tailoring for these risk/protective factors.

Indexed as

Emergency Service, HospitalOpioid-Related DisordersPrescription Drug MisuseAdolescentAdultFemaleHumansMaleProtective FactorsRisk FactorsYoung AdultAlcohol useDrug useEmergency departmentOpioid misuseYoung adults

Identifiers

PMID40763586
PMCPMC12357542

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.