ArticleThe Journal of urology2025
Risk Factors for First-Year Recurrence in Patients With Synchronous Metastatic Renal Cell Carcinoma Undergoing Cytoreductive Nephrectomy and Complete Metastasectomy.
Article in The Journal of urology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Initial and Repeat Metastasis-Directed Therapy in Systemic Therapy-Naïve Oligometastatic Renal Cell Carcinoma: Oncologic Outcomes and Risk-Based Stratification.Annals of surgical oncology · 2026Article
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Authors and funding
19 authors.
Funding
Abstract
purposePatients with metastatic renal cell carcinoma (mRCC) with oligometastatic disease can achieve radiographic disease-free (M1 NED) status after cytoreductive nephrectomy and concurrent complete metastasectomy. This study aimed to evaluate outcomes and identify risk factors associated with metastatic recurrence and overall survival in patients with mRCC M1 NED. MATERIALS AND
methodsPatients with synchronous mRCC who were M1 NED after cytoreductive nephrectomy and concurrent complete metastasectomy from 4 institutions (2010-2020) were identified. Survival outcomes were analyzed by the Kaplan-Meier method. Patients were grouped by early (first year after surgery) recurrence or delayed/no known metastatic recurrence. Logistic regression modeling identified risk factors for first-year recurrence, and decision curve analysis evaluated the utility of a model incorporating identified risk factors.
resultsOne hundred and nine M1 NED patients were identified including 36 patients who had recurrence in the first year after surgery and 73 patients with delayed or no recurrence. First-year recurrence resulted in significantly shorter overall survival compared with those with delayed/no recurrence after 1 year (median 15 vs 97 months, respectively,
conclusionsLiver metastasis, increasing primary tumor size, and elevated preoperative C-reactive protein are associated with increased risk for first-year progression after cytoreductive nephrectomy and complete metastasectomy. Despite radiographic NED status, high-risk patients should be considered for immediate systemic therapy after surgery given poor outcomes.
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