ArticlePLoS neglected tropical diseases2025
Cryptosporidium infection and associated factors among diarrheic children under five years of age in Eastern Ethiopia.
Article in PLoS neglected tropical diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Cryptosporidiosis burden among children younger than 5 years with diarrhea attending Banadir hospital in Mogadishu, Somalia.IJID regions · 2026Article
- Cryptosporidiosis at the human-ruminant interface in Aswan, Egypt: a one health epidemiological study using microscopy, immunofluorescence, and PCR.BMC veterinary research · 2026Article
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11 authors.
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Abstract
backgroundCryptosporidium infection causes diarrhea that may lead to malnutrition, growth faltering, cognitive impairment, and mortality if left untreated. Cryptosporidiosis continues to be a significant public health issue in low-income countries, including Ethiopia. However, its epidemiology among children under five years of age remains understudied. Therefore, this study aimed to determine the prevalence and factors associated with Cryptosporidium infection among diarrheic children under five in Eastern Ethiopia. A cross-sectional study was conducted among children under five years of age attending health centers with diarrhea in Eastern Ethiopia between November 2022 and October 2023. Fecal specimens were analyzed by auramine-phenol staining using light-emitting diode fluorescence microscopy. A structured questionnaire was used to obtain information on sociodemographic and other variables potentially associated with Cryptosporidium infection. Poisson regression with a robust variance model was employed to assess factors associated with Cryptosporidium infection using the prevalence ratio with 95% confidence intervals (CI).
resultsThis study included 756 diarrheic children under five years of age (mean = 20.8 months with a standard deviation of 13.4 and median of 16 months). The prevalence of Cryptosporidium infection was 15.2% (95% CI: 12.7-17.9). Wet season (adjusted prevalence ratio (APR) = 1.7, 95% CI: 1.2-2.4), having caregivers with no formal education (APR = 2.6, 95% CI: 1.1-6.3), presence of a diarrheic member in the household (APR = 1.9, 95% CI: 1.2-3.2), not being exclusively breastfed (APR = 1.6, 95% CI: 1.1-2.3), lack of handwashing practice after toileting (APR = 2.8, 95% CI: 1.7-4.5), and the use of toilet paper after defecation (APR = 1.6, 95% CI: 1.6-3.3) were factors significantly associated with increased risk of Cryptosporidium infection.
conclusionsCryptosporidiosis was highly prevalent in diarrheic children under five years of age in Eastern Ethiopia. Exclusive breastfeeding, improving sanitation, and ensuring proper hygiene practices are essential steps in reducing the risk of Cryptosporidium infection.
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