Evidence map›Paper›PMID 40763107›Full record

ArticleJournal of neurotrauma2025

Association Between Acute Plasma Glial Fibrillary Acidic Protein Levels and White Matter Integrity in Recent Trauma Survivors.

Megan E Huibregtse, Tianyi Li, Nathaniel G Harnett, Esther L Yuh, Timothy D Ely, Tanja Jovanovic, Vince D Calhoun, Thomas C Neylan, Stacey L House, Gari D Clifford and 30 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurotrauma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

40 authors.

Megan E HuibregtseDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.ORCID 0000-0001-6311-8872
Tianyi LiDivision of Depression and Anxiety, McLean Hospital, Belmont, Massachusetts, USA.
Nathaniel G HarnettDivision of Depression and Anxiety, McLean Hospital, Belmont, Massachusetts, USA.
Esther L YuhDepartment of Radiology & Biomedical Imaging, University of California San Francisco, San Francisco, California, USA.
Timothy D ElyDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Tanja JovanovicDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA.
Vince D CalhounTri-Institutional Center for Translational Research in Neuroimaging and Data Science (TReNDS), Georgia State University, Georgia Institute of Technology, Emory University, Atlanta, Georgia, USA.
Thomas C NeylanDepartments of Psychiatry and Neurology, University of California San Francisco, San Francisco, California, USA.
Stacey L HouseDepartment of Emergency Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Gari D CliffordDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, Georgia, USA.
Meredith A BucherInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Sarah D LinnstaedtInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Xinming AnInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Alana C ContiDepartment of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, Michigan, USA.
Antonia V SeligowskiDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Qiao LiDepartment of Biomedical Informatics, Emory University School of Medicine, Atlanta, Georgia, USA.
Daniel G DillonDepartment of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA.
Lisa M VizerDepartment of Medicine, Division of General Medicine and Clinical Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Lauren A McKibbenInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Liz Marie Albertorio-SáezInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Francesca L BeaudoinDepartment of Epidemiology, Brown University, Providence, Rhode Island, USA.
Kevin K W WangCenter for Neurotrauma, Multiomics & Biomarkers, Neuroscience Institute, Department of Neurobiology, Morehouse School of Medicine, Atlanta, Georgia, USA.
Liana MatsonWalter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Steven E HarteDepartment of Anesthesiology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Steven E BruceDepartment of Psychological Sciences, University of Missouri-St. Louis, St. Louis, Missouri, USA.
John P HaranDepartment of Emergency Medicine, University of Massachusetts Chan Medical School, Worcester, Massachusetts, USA.
Alan B StorrowDepartment of Emergency Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Christopher LewandowskiDepartment of Emergency Medicine, Henry Ford Health System, Detroit, Michigan, USA.
Paul I MuseyDepartment of Emergency Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Phyllis L HendryDepartment of Emergency Medicine, University of Florida College of Medicine-Jacksonville, Jacksonville, Florida, USA.
Christopher W JonesDepartment of Emergency Medicine, Cooper Medical School of Rowan University, Camden, New Jersey, USA.
Robert A SworDepartment of Emergency Medicine, Oakland University William Beaumont School of Medicine, Rochester, Michigan, USA.
Claire PearsonDepartment of Emergency Medicine, Wayne State University, Ascension St. John Hospital, Detroit, Michigan, USA.
David A PeakDepartment of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA.
Brian J O'NeilDepartment of Emergency Medicine, Wayne State University, Detroit Receiving Hospital, Detroit, Michigan, USA.
Ronald C KesslerDepartment of Health Care Policy, Harvard Medical School, Boston, Massachusetts, USA.
Karestan C KoenenDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, Massachusetts, USA.
Kerry J ResslerDivision of Depression and Anxiety, McLean Hospital, Belmont, Massachusetts, USA.
Samuel A McLeanInstitute for Trauma Recovery, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Jennifer S StevensDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.

Funding

Longitudinal Assessment of Post-traumatic SyndromesU01MH110925 · NIMH · UNIV OF NORTH CAROLINA CHAPEL HILL · PI KESSLER, RONALD C, KOENEN, KARESTAN C · 2016 to 2020
$25.8M
Clinical Features and Neuropathological Basis of Sleep Wake Behavior in Alzheimer's and PSPR01AG060477 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Lea Tenenholz Grinberg, Thomas C Neylan · 2019 to 2026
$8.2M
Extracellular vesicles as biomarkers of trauma exposure and PTSD riskR01MH129495 · NIMH · UNIVERSITY OF COLORADO DENVER · PI Tracy L Bale, Tanja Jovanovic · 2022 to 2026
$4.0M
TRAUMA RESEARCH FELLOWSHIPT32GM008450 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bruce A Cairns, Anthony G Charles · 1992 to 2026
$3.8M
Investigating Fear System Myelination in PTSD Using In Vivo and Post Mortem DataR01MH132617 · NIMH · NORTHERN CALIFORNIA INSTITUTE/RES/EDU · PI HUBER, BERTRAND R, NEYLAN, THOMAS C · 2023 to 2025
$2.1M
Multimodal characterization of affective visual processing in the early aftermath of traumaK01MH129828 · NIMH · MCLEAN HOSPITAL · PI Nathaniel G Harnett · 2023 to 2026
$719k
Sex differences in traumatic brain injury: Neural circuit mediators of overlapping stress and physical effectsF32MH134528 · NIMH · EMORY UNIVERSITY · PI HUIBREGTSE, MEGAN E · 2023 to 2024
$158k
NIA NIH HHS R01 AG060477NIGMS NIH HHS T32 GM008450NIMH NIH HHS F32 MH134528NIMH NIH HHS K01 MH129828NIMH NIH HHS R01 MH129495NIMH NIH HHS R01 MH132617NIMH NIH HHS U01 MH110925
6 · The paper itself

Abstract

Traumatic brain injuries (TBIs) account for over 2.5 million emergency department (ED) visits each year in the United States. The bulk of TBI research in acute care settings has focused exclusively on individuals who receive computed tomography (CT) scanning. Recently, more sensitive TBI assessment tools have been identified, including blood biomarkers such as glial fibrillary acidic protein (GFAP) and magnetic resonance imaging (MRI) of white matter microstructural integrity. These methods can evaluate for evidence of TBI in CT-negative patients. However, limited prior work has investigated the relationship between blood GFAP levels and white matter microstructural integrity. The present study examined the association between acute (≤72 h) GFAP levels and white matter microstructural integrity at 2 weeks post-trauma among ED patients (

Indexed as

Brain Injuries, TraumaticGlial Fibrillary Acidic ProteinWhite MatterAdultAgedBiomarkersDiffusion Tensor ImagingFemaleHumansMaleMiddle AgedYoung AdultBiomarkersGFAP protein, humanGlial Fibrillary Acidic Proteindiffusion neuroimagingglial fibrillary acidic proteinpsychological traumasex differences

Identifiers

PMID40763107
PMCPMC12668301

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.