Observational studyActa obstetricia et gynecologica Scandinavica2025
Difference in pre- and postnatal prevalence of congenital cardiac tumors in a large population-based cohort.
Observational study in Acta obstetricia et gynecologica Scandinavica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02753348 (Copenhagen Baby Heart), which is not on this map. Cited by 2 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Copenhagen Baby Heart
Who cites it
2 citing papers in PubMed.
- Echogenicities in the Fetal Heart: Echocardiographic Evaluation, Differential Diagnosis and Clinical Outcomes.Pediatric cardiology · 2026Review
- Difference in pre- and postnatal prevalence of congenital cardiac tumors in a large population-based cohort.Acta obstetricia et gynecologica Scandinavica · 2025Observational
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Authors and funding
10 authors.
Funding
Abstract
introductionCardiac tumors in children are rare. Rhabdomyomas are the most common type in newborns, often associated with tuberous sclerosis. The exact prevalence of neonatal cardiac tumors is unknown. This study aimed to determine the pre- and postnatal prevalence of cardiac tumors in a population-based cohort. MATERIAL AND
methodsThis cross-sectional study collected data from two sources: (1) all fetuses who underwent routine prenatal malformation scans (Weeks 18-21) with expected delivery within the study period (April 2016 and October 2018), and (2) all newborns who underwent systematic transthoracic echocardiography in the population-based Copenhagen Baby Heart Study within the study period. Medical charts provided follow-up data. CLINICAL
trial registrationclinicaltrials.gov; identifier: NCT02753348.
resultsAmong 47 228 live-births (51% male) in the study period, 1) 44 963 fetuses were scanned, with one prenatally diagnosed with a cardiac tumor (0.002% prevalence). Fetal autopsy revealed a cardiac rhabdomyoma. 2) Of 25 590 newborns (age 12 ± 8 days, 52% male) scanned, 7 had cardiac tumors (0.027% prevalence), a 14-fold higher prevalence than prenatally (p = 0.005). Tumors were located in the ventricles, predominantly (86%) multifocal, in otherwise normal hearts. Three affected newborns (43%) had tuberous sclerosis; the remaining four (57%) exhibited spontaneous tumor regression. Retrospective analysis of prenatal scans suspected a ventricular tumor in 1 of the 7 cases.
conclusionsIn a large, contemporary cohort, the pre- and postnatal prevalence of congenital cardiac tumors was 0.002% and 0.027%. This likely reflects the growth pattern of myocardial tumors and underscores the importance of gestational age for detection. Tumors in newborns were associated with tuberous sclerosis in 43%, and the remaining regressed spontaneously.
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