Article in Proceedings of the National Academy of Sciences of the United States of America, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Cytochrome bFree radical biology & medicine · 2026
Article
CytochromebioRxiv : the preprint server for biology · 2025
Article
4 · The record
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what money
Authors and funding
18 authors.
Matthew R DentHeart, Lung, Blood, and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0002-7704-4867
Anthony W DeMartinoDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.ORCID 0000-0001-5303-5758
Qinzi XuDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.
Xiukai ChenHeart, Lung, Blood, and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Alay GandhiDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.
Hyon S HwangDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.ORCID 0000-0001-8117-0199
Kaitlin A BocianHeart, Lung, Blood, and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.
Jacob E CorrentiDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.ORCID 0009-0006-7074-4218
Youmna AbdelghanyDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.
Elmira AlipourDepartment of Physics, Wake Forest University, Winston-Salem, NC 27109.ORCID 0000-0003-3507-4010
K Burak UcerDepartment of Physics, Wake Forest University, Winston-Salem, NC 27109.
Stephen R BakerDepartment of Physics, Wake Forest University, Winston-Salem, NC 27109.ORCID 0000-0002-3147-4925
Ajay Ram Srimath KandadaDepartment of Physics, Wake Forest University, Winston-Salem, NC 27109.ORCID 0000-0002-7420-1150
Angka BulbulDepartment of Physics, Wake Forest University, Winston-Salem, NC 27109.
Daniel B Kim-ShapiroDepartment of Physics, Wake Forest University, Winston-Salem, NC 27109.ORCID 0000-0003-4383-3101
Jason J RoseDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.
Jesus TejeroHeart, Lung, Blood, and Vascular Medicine Institute, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261.ORCID 0000-0003-3245-9978
Mark T GladwinDepartment of Medicine, University of Maryland School of Medicine, Baltimore, MD 21201.ORCID 0000-0001-7267-9006
Funding
Antidote for inhaled CO poisoning based on mutationally engineered neuroglobinR01HL125886 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Mark T Gladwin, Jesus Tejero Bravo · 2015 to 2026
$7.9M
Translational Pulmonary Vascular BiologyT32HL110849 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Sruti Shiva · 2012 to 2026
$5.0M
Optimization of a carbon monoxide (CO) sensing hemoprotein for applications as an antidote for CO poisoning and a biosensor for CO detection in living cellsR00HL168224 · NHLBI · WAYNE STATE UNIVERSITY · PI Matthew Ryan Dent · 2024 to 2026
$746k
Optimization of a carbon monoxide (CO) sensing hemoprotein for applications as an antidote for CO poisoning and a biosensor for CO detection in living cellsK99HL168224 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DENT, MATTHEW RYAN · 2023 to 2024
$326k
Development of a carbon monoxide scavenging hemoprotein as a novel antidotal therapy to treat inhaled CO poisoningF32HL162381 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DENT, MATTHEW RYAN · 2022 to 2022
$77k
HHS | NIH (NIH) F32HL162381HHS | NIH (NIH) K99HL168224HHS | NIH (NIH) R00HL168224HHS | NIH (NIH) R01HL125886HHS | NIH (NIH) T32HL110849Martin Family Foundation (The Martin Family Foundation) GiftNHLBI NIH HHS F32 HL162381NHLBI NIH HHS K99 HL168224NHLBI NIH HHS R00 HL168224NHLBI NIH HHS R01 HL125886NHLBI NIH HHS T32 HL110849U.S. Department of Defense (DOD) W81XWH2210198
6 · The paper itself
Abstract
Carbon monoxide (CO) poisoning causes 50,000 to 100,000 emergency department visits and ~1,500 deaths in the United States annually. Current treatments are limited to supplemental and/or hyperbaric oxygen to accelerate CO elimination. Even with oxygen therapy, nearly half of CO poisoning survivors suffer long-term cardiac and neurocognitive deficits related to slow CO clearance, highlighting a need for point of care antidotal therapies. Given the natural interaction between CO and ferrous heme, we hypothesized that the hemoprotein RcoM, a transcriptional regulator of microbial CO metabolism, would make an ideal platform for CO-selective scavenging from endogenous hemoproteins. We engineered an RcoM truncate (RcoM-HBD-CCC) that exhibits high CO affinity (
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Engineering a highly selective, hemoprotein-based scavenger as a carbon monoxide poisoning antidote with no hypertensive effect. · full record | OpenQuestion