Evidence map›Paper›PMID 40762941›Full record

ArticleScience China. Life sciences2026

Galacto-oligosaccharides enrich galactosidase-encoded rather than all Lachnospiraceae bacteria to redress abnormal gut microbiota and lipid metabolism in pregnancy.

Rujun Wei, Jiyun Long, Haoxue Xia, Yanni Sun, Lin Zhang, Xiaoqing Li, Hongping Zhang, Run Wang, Shengtao Gao, Yunwei Chen and 3 more

Abstract read
PubMed Publisher
In one paragraph

Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Rujun WeiCollege of Food Science & Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Jiyun LongCollege of Food Science & Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Haoxue XiaCollege of Food Science & Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Yanni SunElectrical Engineering, City University of Hong Kong, Hong Kong SAR, 999077, China.
Lin ZhangMicrobiota I-Center (MagIC), Hong Kong SAR, 999077, China.
Xiaoqing LiWenzhou People's Hospital/Wenzhou Maternal and Child Health Care Hospital/The Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, 325000, China.
Hongping ZhangWenzhou People's Hospital/Wenzhou Maternal and Child Health Care Hospital/The Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou, 325000, China.
Run WangCollege of Food Science & Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Shengtao GaoCollege of Food Science & Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Yunwei ChenCollege of Food Science & Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Yun GuCollege of Agronomy and Biotechnology, China Agricultural University, Beijing, 100193, China.
Xiaoya WangCollege of Food Science & Nutritional Engineering, China Agricultural University, Beijing, 100083, China.
Jinfeng WangCollege of Food Science & Nutritional Engineering, China Agricultural University, Beijing, 100083, China. wangjf@cau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among the various pregnancy complications, gestational diabetes mellitus (GDM) is one of the most prevalent and damaging adverse conditions. GDM is characterised by dysregulated gut microbiota and dysglycaemia. There is a keen search for active ingredients that can modify gut dysbiosis and glycaemic imbalances. In this study, the effects of dietary supplementation with high fibre and galacto-oligosaccharides (GOS) on GDM were evaluated. We found that GOS effectively alleviated blood glucose, hepatic inflammatory response, and lipid metabolism in high-fat-induced GDM mice. Furthermore, GOS redressed GDM-associated gut dysbiosis and altered glycerolipid metabolic pathways. GOS supplementation significantly downregulated the levels of fat synthesis genes and inflammatory factors in the liver and upregulated the expression of lipolytic catabolic genes (Cyp4a10). In dietary GOS supplementation, Lachnospiraceae bacteria strongly co-occurred with saturated lysophosphatidylcholine in the glycerolipid metabolic pathway. Metagenomic analyses illustrated that Lachnospiraceae bacteria-hosted α-galactosidase genes enriched upon GOS intake. GOS supplementation reduces lipopolysaccharide (LPS) entry into the systemic circulation by repairing intestinal mucosal damage, inhibits inflammatory cell production by reducing hepatic and intestinal Toll-like receptor-4 (TLR-4) expression and potentially ameliorates blood glucose dysregulation in GDM by modulating glycerophospholipid metabolism. These results revealed that dietary supplementation of GOS during pregnancy may be a promising intervention against GDM.

Indexed as

Diabetes, GestationalGastrointestinal MicrobiomeLipid MetabolismOligosaccharidesAnimalsBlood GlucoseDietary SupplementsDysbiosisFemaleLiverMicePregnancyBlood GlucoseOligosaccharidesgalacto-oligosaccharidesgalactosidasegut microbiotaLachnospiraceaelipid metabolism

Identifiers

PMID40762941

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.