ArticleJournal of gastrointestinal cancer2025
Trends and Disparities in Mortality Due to Gastric Malignancies the United States: A Nationwide Analysis from 1999 to 2020.
Article in Journal of gastrointestinal cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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Who cites it
2 citing papers in PubMed.
- Examining the link between tobacco use and gastric cancer mortality: A US population-based perspective (2003 to 2023).Medicine · 2026Article
- Efficacy and safety of Busulfan-Fludarabine versus Busulfan-Cyclophosphamide as a conditioning regimen prior to hematopoietic stem cell transplant in hematologic malignancy patients: a meta-analysis of randomized controlled trials and observational studies.Therapeutic advances in hematology · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGastric malignancies remain a significant public health concern and a major contributor to cancer-related mortality worldwide. This study aimed to analyze trends and disparities in gastric malignancy mortality across socio-demographic and regional factors in the United States (US) from 1999 to 2020.
methodsA retrospective analysis was conducted using CDC WONDER data from 1999 to 2020 for adults aged ≥ 25 years. Data on demographics (age, sex, race/ethnicity), urban-rural classification, and regional trends were extracted. Age-adjusted mortality rates (AAMR) were calculated using the 2000 U.S. population as a reference, with trends analyzed using Joinpoint regression to determine annual percentage changes (APC) with statistical significance (P < 0.05).
resultsBetween 1999 and 2020, 276,023 deaths due to gastric malignancies were recorded, with 59.3% occurring among males. The AAMR declined from 7.94 in 1999 to 4.66 in 2020, with an overall AAMR of 5.82. The 65 + age group had the highest AAMR (20.83), while the 25-44 age group had the lowest (0.74). Males consistently reported higher AAMRs (7.60) than females (4.85). NH Black individuals had the highest overall AAMR (10.82), while NH White individuals had the lowest (4.62). Urban areas had higher AAMRs (5.95) than rural areas (5.07).
conclusionMortality from gastric malignancies has declined in the U.S. from 1999 to 2020; however, higher mortality rates in NH Black individuals, males, and urban dwellers highlight the need for targeted interventions and equitable access to prevention and treatment resources. Future research should focus on identifying actionable solutions to mitigate these gaps.
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