Evidence map›Paper›PMID 40762924›Full record

ArticleGeneral thoracic and cardiovascular surgery2026

Novel nonbiological surgical sealant to control air leakage after lung resection.

Akira Kohno, Hiroyuki Kamata, Shohei Ishikawa, Takamasa Sakai, Masaaki Sato, Jun Nakajima

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in General thoracic and cardiovascular surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Akira KohnoDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan. a.kohno.0422@gmail.com.ORCID http://orcid.org/0000-0003-2716-8770
Hiroyuki KamataDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Shohei IshikawaDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Takamasa SakaiDepartment of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan.
Masaaki SatoDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.
Jun NakajimaDepartment of Thoracic Surgery, The University of Tokyo Graduate School of Medicine, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesPulmonary air leakage is a major complication in patients undergoing lung resection, particularly with the increasing use of segmentectomy in Japan. We developed a non-biological polyethylene glycol (PEG) hydrogel sealant to control pulmonary air leakage. This study compared the adhesiveness, expansion, and safety of PEG hydrogel with those of fibrin glue.

methodsAdhesiveness was evaluated using isolated ventilated pig lungs subjected to a stepwise increase in airway pressure. A pleural defect was created, and PEG hydrogels with elastic moduli (G') = 38.2, 646, 3900, and 7780 Pa were applied alongside fibrin glue with G' = 7260 Pa. PEG hydrogel with G' = 7780 Pa and fibrin glue were also applied to isolated deflated pig lungs, which were then inflated to assess expandability. Additionally, a pleural defect was created in rat lungs, and PEG hydrogel or fibrin glue was applied. The rats were observed for 2 and 4 weeks to evaluate safety.

resultsNo air leakage was observed in pig lungs treated with PEG hydrogel with G' = 7780 Pa. In contrast, air leakage occurred with PEG hydrogels of other stiffnesses and fibrin glue. PEG hydrogel with G' = 7780 Pa exhibited strong adherence to the pleural surface compared to fibrin glue following lung expansion. All rats survived, and the PEG hydrogel remained intact without peeling at 2 and 4 weeks.

conclusionThe PEG hydrogel is entirely non-biological and poses no infection risk. It demonstrates potential advantages over fibrin glue in preventing postoperative air leakage.

Indexed as

Fibrin Tissue AdhesiveHydrogelsLungPneumonectomyPneumothoraxPolyethylene GlycolsTissue AdhesivesAdhesivenessAnimalsDisease Models, AnimalMaleRats, Sprague-DawleySwineTime FactorsFibrin Tissue AdhesiveHydrogelsPolyethylene GlycolsTissue AdhesivesFibrin glueLung resectionPolyethylene glycol (PEG) hydrogelPostoperative complicationsPulmonary air leakage

Identifiers

PMID40762924

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.