Evidence map›Paper›PMID 40762897›Full record

ArticleClinical rheumatology2025

Integrative GWAS and Mendelian randomization study of rheumatoid arthritis based on the 2019 UK Biobank questionnaire.

Tengda Cai, Yiwen Tao, Qi Pan, Luning Yang, Sen Lin, Anal Chatterjee, Weihua Meng, Jingjing Song

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Article in Clinical rheumatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tengda CaiNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100, China.ORCID http://orcid.org/0000-0003-1617-506X
Yiwen TaoNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100, China.ORCID http://orcid.org/0009-0000-0102-4205
Qi PanNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100, China.ORCID http://orcid.org/0000-0003-0135-9122
Luning YangNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100, China.ORCID http://orcid.org/0000-0001-9056-5950
Sen LinNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100, China.ORCID http://orcid.org/0000-0002-7695-0964
Anal ChatterjeeDepartment of Mathematics, Barrackpore Rastraguru Surendranath College, Barrackpore, Kolkata, 700120, India.ORCID http://orcid.org/0000-0001-5780-9511
Weihua MengNottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, 315100, China. weihua.meng@nottingham.edu.cn.ORCID http://orcid.org/0000-0001-5388-8494
Jingjing SongDepartment of Internal Medicine, Huzhou Wuxing Hospital of Chinese Medicine, Huzhou, 313000, China. songjingjinghz@gmail.com.ORCID http://orcid.org/0009-0008-4934-402X

Funding

Ningbo International Collaboration Program 2023 2023H025Pioneer and Leading Goose R&D Program of Zhejiang Province 2023 2023C04049
6 · The paper itself

Abstract

introductionRheumatoid arthritis (RA) is the most prevalent autoimmune inflammatory joint disorder worldwide. We aimed to identify the genetic variants contributing to RA and investigate the potential influence of related diseases on RA risk.

methodsWe performed genome-wide association studies (GWAS) on RA using the 2019 UK Biobank pain questionnaire. We conducted a primary GWAS (9,389 RA cases; 132,108 controls) and separate sex-stratified GWAS for females (4,832 cases; 75,184 controls) and males (4,557 cases; 56,924 controls). We incorporated 12 phenotypes from downstream analyses, such as genetic correlation analyses, transcriptome-wide association studies (TWAS), phenome-wide association studies (PheWAS), and Mendelian randomization (MR) studies to determine causal relationships with RA.

resultsTwo loci reached genome-wide significance in the primary GWAS. The top SNP, rs35139284 (p = 3.67 × 10

conclusionOur findings confirmed an RA locus at chromosome 6 and highlighted associations between RA and a spectrum of immune-related and inflammatory phenotypes. Further analyses may provide greater insights into the genetic architecture of RA. Key Points • Leveraging the 2019 UK Biobank pain questionnaire, our genome-wide association studies (GWAS) confirmed a risk locus on chromosome 6 associated with rheumatoid arthritis (RA). • Sex-stratified analyses revealed significant differences in RA susceptibility between males and females, paving the way for personalized therapeutic strategies by demonstrating sex-specific genetic risks. • Mendelian randomization underscored the associations of both asthma and eosinophils with RA while identifying key hub genes, thereby deepening our understanding of RA's underlying molecular mechanisms and suggesting potential targets for future interventions.

Indexed as

Arthritis, RheumatoidAgedBiological Specimen BanksFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMendelian Randomization AnalysisMiddle AgedPolymorphism, Single NucleotideSurveys and QuestionnairesUK BiobankUnited KingdomGeneticsGenome-wide association studyMendelian randomizationRheumatoid arthritis

Identifiers

PMID40762897

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.