SynthesisInternational journal of colorectal disease2025
Therapeutic strategies for low anterior resection syndrome: an umbrella review of systematic reviews.
Synthesis in International journal of colorectal disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- [Anorectal functional disorders following organ-preserving treatment and resection of rectal cancer].Chirurgie (Heidelberg, Germany) · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
purposeThe purpose of this umbrella review was to systematically evaluate the effectiveness of therapeutic strategies for managing low anterior resection syndrome following sphincter-preserving surgery for rectal cancer and to provide evidence-based recommendations for clinical practice.
methodsA systematic literature search was performed across five electronic databases. Two independent reviewers screened titles/abstracts, assessed full-text studies, and extracted data, with discrepancies resolved by consensus. The study adhered to AMSTAR-2 and GRADE frameworks for methodological quality and evidence certainty assessments.
resultsSixteen systematic reviews (including nine meta-analyses) published between 2018 and 2025 were analyzed, covering therapeutic strategies such as transanal irrigation, pelvic floor rehabilitation, sacral nerve stimulation, percutaneous tibial nerve stimulation, pelvic floor muscle training, and biofeedback therapy. For quality assessment, two studies were evaluated as moderate quality, five as low, and nine as critically low.
conclusionTAI and PFR are recommended as first-line therapies for LARS, while SNS or PTNS may be considered for refractory cases, especially those with predominant fecal incontinence. Future research should focus on standardizing protocols, improving patient compliance, and conducting high-quality randomized controlled trials to strengthen the evidence base.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.