Evidence map›Paper›PMID 40762785›Full record

ArticleGeroScience2026

Chronic inflammation mediates the relationship between physical activity and telomere length.

Anamika Nanda, Daniel H Aslan, M Katherine Sayre, Pradyumna K Bharadwaj, Madeline Ally, Hyun Song, Amit Arora, Silvio Maltagliati, Mark H C Lai, Rand R Wilcox and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Anamika NandaHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA. anamikan@usc.edu.ORCID 0000-0001-5396-5592
Daniel H AslanHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
M Katherine SayreDepartment of Anthropology, University of California Santa Barbara, Santa Barbara, CA, USA.
Pradyumna K BharadwajDepartment of Psychology, University of Arizona, Tucson, AZ, USA.
Madeline AllyDepartment of Psychology, University of Arizona, Tucson, AZ, USA.
Hyun SongDepartment of Psychology, University of Arizona, Tucson, AZ, USA.
Amit AroraDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Silvio MaltagliatiHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.
Mark H C LaiDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Rand R WilcoxDepartment of Psychology, University of Southern California, Los Angeles, CA, USA.
Yann C KlimentidisDepartment of Epidemiology and Biostatistics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ, USA.
Gene E AlexanderDepartment of Psychology, University of Arizona, Tucson, AZ, USA.
David A RaichlenHuman and Evolutionary Biology Section, Department of Biological Sciences, University of Southern California, Los Angeles, CA, USA.

Funding

Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5M
Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI ALIREZA ATRI · 2021 to 2026
$24.9M
Revitalizing Cognition in Older Adults at Risk for Alzheimer's Disease with Near-Infrared Photobiomodulation: Diversity SupplementR01AG064587 · NIA · UNIVERSITY OF FLORIDA · PI ALEXANDER, GENE E, BOWERS, DAWN · 2019 to 2023
$4.0M
Inactivity, sedentary behavior, and the risk for Alzheimer’s disease in middle aged to older adultsR01AG072445 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI GENE E ALEXANDER, Yann Charles Klimentidis · 2022 to 2026
$3.3M
Physical activity predictors of cognitive and brain health in the risk for Alzheimer's diseaseR56AG067200 · NIA · UNIVERSITY OF ARIZONA · PI ALEXANDER, GENE E, RAICHLEN, DAVID · 2020 to 2020
$767k
National Institute of Health R01AG064587NIA NIH HHS P30AG019610NIA NIH HHS P30AG072980NIA NIH HHS R01 AG064587NIA NIH HHS R01 AG072445NIA NIH HHS R01AG72445NIA NIH HHS R56 AG067200NIA NIH HHS R56AG067200
6 · The paper itself

Abstract

A physically active lifestyle benefits cellular aging, however the mechanisms linking physical activity (PA) with longevity remain unclear. PA is associated with longer telomere length (TL), while shorter TL has been associated with increased cellular aging. Some research suggests increased levels of inflammatory markers, such as C-reactive protein (CRP), are associated with telomere dysfunction. We tested the hypothesis that CRP levels mediate the association between PA and TL. Using data from the UK Biobank, we analyzed adjusted leukocyte T/S ratio (relative telomere to single gene copy), serum CRP, and moderate-to-vigorous physical activity (MVPA) data via device-measured actigraphy. We applied general linear regressions and a causal mediation analysis with 10,000 bootstraps while controlling for a range of covariates (age, BMI, smoking status, sex, ethnicity, time between data collection, time wearing the accelerometer, and the Townsend Deprivation Index). Variables of interest were transformed to approximate normality. A total of 79,873 participants were included in the final analytic sample. MVPA and CRP were both significant predictors of TL (β

Indexed as

ExerciseInflammationTelomereTelomere HomeostasisAgedBiomarkersChronic DiseaseC-Reactive ProteinFemaleHumansMaleMiddle AgedBiomarkersC-Reactive ProteinC-reactive proteinEpidemiologyPhysical activityTelomere lengthUK Biobank

Identifiers

PMID40762785
PMCPMC12972198

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.