Exploring cadmium-binding proteins in Japanese scallops Mizuhopecten yessoensis: isolation and characterization.

Zehua Zheng, Yuto Namikawa, Yugo Kato, Peng Lu, Lumi Negishi, Hitoshi Kurumizaka, Koji Nagata, Michio Suzuki

Abstract read

In one paragraph

Article in Environmental science and pollution research international, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Zehua Zheng *Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo, 113-8657, Japan.

Yuto Namikawa *Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo, 113-8657, Japan.

Yugo KatoDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo, 113-8657, Japan.

Peng LuDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo, 113-8657, Japan.

Lumi NegishiInstitute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo, 113-0032, Japan.

Hitoshi KurumizakaInstitute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo, 113-0032, Japan.

Koji NagataDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo, 113-8657, Japan.

Michio SuzukiDepartment of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-Ku, Tokyo, 113-8657, Japan. amichio@g.ecc.u-tokyo.ac.jp.ORCID http://orcid.org/0000-0001-6150-8957

Funding

Japan Society for the Promotion of Science JP19H05771

6 · The paper itself

Abstract

Scallops (Mizuhopecten yessoensis) accumulate abnormal levels of cadmium (Cd) in their bodies; however, the chemical form of Cd in vivo remains unclear. In this study, Cd concentrations in various scallop tissues were measured, revealing that Cd predominantly accumulated as a water-soluble component within the midgut gland. High-performance liquid chromatography combined with the post-column tetraphenylporphyrin tetrasulfonic acid (TPPS) experiment revealed that the molecular weight of the Cd-binding substances was approximately 44 kDa. Moreover, Cd-immobilized affinity chromatography and CdS precipitation identified M. yessoensis meprin A subunit alpha-like (myMEP1A) as a Cd-binding protein. The myMEP1A gene was specifically expressed in the midgut gland. TPPS measurements indicated that myMEP1A exhibited strong Cd-binding activity. These results suggested that myMEP1A is a protein responsible for Cd accumulation in the midgut gland.

Indexed as

CadmiumCarrier ProteinsPectinidaeAnimalsMetallothioneinCadmiumcadmium-binding proteinCarrier ProteinsMetallothioneinAccumulationCadmiumCd-binding substanceIdentificationMidgut glandMizuhopecten yessoensisPurificationScallop

Identifiers

PMID40762738

DOI10.1007/s11356-025-36799-1

PMCPMC12357810

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.