ArticleEuropean archives of psychiatry and clinical neuroscience2026
Functional connectivity of the nucleus accumbens and the amygdala in offspring of parents with bipolar or major depressive disorder.
Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Major depressive disorder (MDD) and bipolar disorder (BD) are mood disorders characterized by impaired emotional and reward processing. Two important regions for emotion processing and reward processing are the amygdala and the nucleus accumbens, respectively. Notably, offspring of parent with MDD or BD (OS-MDD and OS-BD) are at higher risk of developing these disorders. However, functional connectivity studies using these regions as seeds in OS-BD and OS-MDD are scarce. Included are 50 OS-BD, 150 OS-MDD and 150 offspring with no parental history of psychopathology (control group) using the Healthy Brain Network biobank. We conducted whole-brain seed-to-voxel analyses using the amygdala and nucleus accumbens as seeds to compare functional connectivity between the three groups. For the analysis using the left amygdala, we found that the OS-MDD group displayed increased connectivity compared to both groups between this seed and the left postcentral gyrus, the right auditory cortex as well as the bilateral temporoparietal junction. These results could be linked to somatic complaints, negative bias towards words and social cues, respectively. Regarding the right NAc, we found aberrant connectivity with the left postcentral gyrus and supramarginal gyrus which reflected higher connectivity in the OS-MDD compared to the OS-BD group. This result could represent a link between reward processing and somatic symptoms. We found no difference between the OS-BD and controls. Therefore, more studies involving larger samples are needed to clarify the connectivity patterns in OS-BD. Moreover, longitudinal studies are required to better understand these connectivity patterns when symptoms of MDD or BD emerges.
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