Imaging in clinical trials of rheumatoid arthritis: where are we in 2025?

Mikkel Østergaard, Magalie Alice Janine Rolland, Lene Terslev

Abstract readReview

In one paragraph

Review in Skeletal radiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Proton-density fat-saturated non-contrast MR imaging is comparable to post-contrast MR imaging for revealing wrist synovitis.Insights into imaging · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Mikkel ØstergaardCopenhagen Center for Arthritis Research (COPECARE), Center for Rheumatology and Spine Diseases, Centre for Head and Orthopaedics, Copenhagen University Hospital Rigshospitalet, Valdemar Hansens Vej 17, 2600, Glostrup, Denmark. mo@dadlnet.dk.

Magalie Alice Janine RollandDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Lene TerslevDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Accurate detection and assessment of inflammatory activity is crucial not only for diagnosing patients with rheumatoid arthritis but also for effective monitoring of treatment effect. Ultrasound and magnetic resonance imaging (MRI) have both been shown to be truthful, reproducible, and sensitive to change for inflammation in joints and tendon sheaths and have validated scoring systems, which altogether allow them to be used as outcome measurement instruments in clinical trials. Furthermore, MRI also allows sensitive and discriminative assessment of structural damage progression in RA, also with validated outcome measures. Other relevant imaging techniques, including the use of artificial intelligence, pose interesting possibilities for future clinical trials and will be briefly addressed in this review article.

Indexed as

Arthritis, RheumatoidClinical Trials as TopicMagnetic Resonance ImagingArtificial IntelligenceHumansUltrasonographyClinical trialsComputed tomographyFluorescence optical imagingImagingMRIRadiographyRheumatoid arthritisUltrasound

Identifiers

PMID40762694

DOI10.1007/s00256-025-05004-2

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.