Evidence map›Paper›PMID 40762641›Full record

ArticleLab on a chip2025

A lung tumor-on-a-chip model recapitulates the effect of hypoxia on radiotherapy response and FDG-PET imaging.

Rohollah Nasiri, Myra Kurosu Jalil, Veronica Ibanez Gaspar, Andrea Sofia Flores Perez, Hieu Thi Minh Nguyen, Syamantak Khan, Sindy K Y Tang, Yunzhi Peter Yang, Guillem Pratx

Abstract read
In one paragraph

Article in Lab on a chip, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. The Next Frontier in Quantitative Co-Clinical Imaging to Advance Functional Precision Oncology.Clinical cancer research : an official journal of the American Association for Cancer Research · 2026
    Article
  2. PHYTO-PET - Imaging plant physiology on a long-axial field-of-view PET scanner.European journal of nuclear medicine and molecular imaging · 2026
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Rohollah NasiriDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA. pratx@stanford.edu.ORCID 0000-0002-8245-692X
Myra Kurosu JalilDepartment of Mechanical Engineering, Stanford University, Stanford, CA, USA.ORCID 0000-0002-9363-4592
Veronica Ibanez GasparDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA. pratx@stanford.edu.ORCID 0000-0003-3746-1807
Andrea Sofia Flores PerezDepartment of Bioengineering, Stanford University School of Engineering, 443 Via Ortega, Stanford, CA 94305, USA.ORCID 0009-0008-0137-9821
Hieu Thi Minh NguyenDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA. pratx@stanford.edu.ORCID 0000-0003-2094-4773
Syamantak KhanDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA. pratx@stanford.edu.ORCID 0000-0002-5864-1842
Sindy K Y TangDepartment of Mechanical Engineering, Stanford University, Stanford, CA, USA.ORCID 0000-0003-1465-2432
Yunzhi Peter YangDepartment of Bioengineering, Stanford University School of Engineering, 443 Via Ortega, Stanford, CA 94305, USA.ORCID 0000-0002-3891-0574
Guillem PratxDepartment of Radiation Oncology, Stanford University, Stanford, CA, USA. pratx@stanford.edu.ORCID 0000-0002-0247-6470

Funding

Stanford Molecular Imaging Scholars (SMIS) ProgramT32CA118681 · NCI · STANFORD UNIVERSITY · PI CRAIG S LEVIN · 2016 to 2026
$4.3M
Preclinical microphysiological tumor models for nuclear medicineR01CA268514 · NCI · STANFORD UNIVERSITY · PI Guillem Pratx, JOHN B SUNWOO · 2023 to 2026
$2.1M
A Novel Assay to Individualize Resensitization of Iodine-Refractory Thyroid CancerR61CA278459 · NCI · STANFORD UNIVERSITY · PI PRATX, GUILLEM · 2023 to 2025
$639k
NCI NIH HHS R01 CA268514NCI NIH HHS R61 CA278459NCI NIH HHS T32 CA118681
6 · The paper itself

Abstract

Most solid tumors contain regions of hypoxia that pose a significant challenge to the efficacy of radiation therapy. This study introduces a novel 3D lung tumor-on-a-chip (ToC) model designed to replicate the hypoxic tumor microenvironment

Indexed as

Fluorodeoxyglucose F18Lab-On-A-Chip DevicesLung NeoplasmsPositron-Emission TomographyCell HypoxiaCell Line, TumorHumansTumor MicroenvironmentFluorodeoxyglucose F18

Identifiers

PMID40762641
PMCPMC12364444

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.