Evidence map›Paper›PMID 40762579›Full record

ArticleMicrobiology spectrum2025

Detection of serum anti-candidalysin IgG by indirect ELISA: a novel auxiliary tool for diagnosing invasive candidiasis in a preliminary pediatric study.

Ting Luo, Xun Li, Haipeng Yan, Ling Gong, Longlong Xie, Xiangyu Wang, Jiaotian Huang, Yufan Yang, Xiao Li, Yingying Zhang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Overview of Risk Factors and Diagnosis of Invasive Candidiasis.Journal of fungi (Basel, Switzerland) · 2026
    Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ting LuoPediatrics Research Institute of the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.ORCID 0009-0007-7295-4494
Xun LiPediatrics Research Institute of the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.
Haipeng YanDepartment of Pediatric Intensive Care Unit & Hunan Provincial Key Laboratory of Emergency Medicine for Children, Hunan Children's Hospital, Changsha, China.
Ling GongDepartment of Pediatric Intensive Care Unit & Hunan Provincial Key Laboratory of Emergency Medicine for Children, Hunan Children's Hospital, Changsha, China.
Longlong XiePediatrics Research Institute of the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.
Xiangyu WangPediatrics Research Institute of the Affiliated Children's Hospital of Xiangya School of Medicine, Central South University (Hunan Children's Hospital), Changsha, China.
Jiaotian HuangDepartment of Pediatric Intensive Care Unit & Hunan Provincial Key Laboratory of Emergency Medicine for Children, Hunan Children's Hospital, Changsha, China.
Yufan YangDepartment of Pediatric Intensive Care Unit & Hunan Provincial Key Laboratory of Emergency Medicine for Children, Hunan Children's Hospital, Changsha, China.
Xiao LiUniversity of South China Hengyang Medical School, Hengyang, China.
Yingying ZhangDepartment of Pediatric Intensive Care Unit, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Guoping LuDepartment of Pediatric Intensive Care Unit, Children's Hospital of Fudan University, National Children's Medical Center, Shanghai, China.
Zhenghui XiaoDepartment of Pediatric Intensive Care Unit & Hunan Provincial Key Laboratory of Emergency Medicine for Children, Hunan Children's Hospital, Changsha, China.ORCID 0000-0003-2056-8798
Xiulan LuDepartment of Pediatric Intensive Care Unit & Hunan Provincial Key Laboratory of Emergency Medicine for Children, Hunan Children's Hospital, Changsha, China.ORCID 0000-0003-3328-5623

Funding

Hunan Provincial Health High-level Talent Scientific research project R2023143Hunan Provincial Health High-level Talent Scientific research project R2023156Hunan Provincial Natural Science Foundation of China 2023JJ30324Ministry of Science and Technology in Hunan Provincial of China 2018TP1028National Key Research and Development Program of China 2021YFC2701800,2021YFC2701805Natural Science Foundation of Hunan Province 2024JJ5217Shanghai Municiple Science and Technology Major Project ZD2021CY001
6 · The paper itself

Abstract

Invasive candidiasis (IC) is the most common fungal infection in clinical settings, yet early diagnosis remains challenging. Candidalysin, a key virulence factor in invasive infections, exhibits site-specific pathogenicity. Our study identifies candidalysin as a serodominant antigenic peptide and reveals significantly elevated serum anti-candidalysin IgG levels in IC across diverse anatomical sites, suggesting its potential as a novel diagnostic biomarker. To evaluate this, we developed an indirect enzyme-linked immunosorbent assay (ELISA) to quantify serum anti-candidalysin IgG. The assay was validated in two distinct validation subsets using a 5-year cohort comprising 121 proven, probable, or possible IC cases from Hunan Children's Hospital, alongside 105 non-IC controls (patients with other infections and healthy individuals). In validation set 1, comparing proven IC cases (

Indexed as

Antibodies, FungalCandidiasis, InvasiveFungal ProteinsImmunoglobulin GAdolescentBiomarkersChildChild, PreschoolEnzyme-Linked Immunosorbent AssayFemaleHumansInfantMaleROC CurveSensitivity and SpecificityAntibodies, FungalBiomarkersFungal ProteinsImmunoglobulin GbiomarkerCandida albicansdiagnosisimmunoserologyinvasive candidiasis

Identifiers

PMID40762579
PMCPMC12403709

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.