Evidence map›Paper›PMID 40762578›Full record

ArticleMicrobiology spectrum2025

Use of the bacteriophage-derived endolysin CHAPK-SH3blys as a potent novel treatment for biofilm-associated

Hawraa Shahrour, Daniela Alves Ferreira, Deirdre Fitzgerald-Hughes, James P O'Gara, Aidan Coffey, Eoghan O'Neill

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Prophages in Skin Pathogens: From Virulence to Therapy.Pathogens (Basel, Switzerland) · 2026
    Review
  4. Eradication ofInternational journal of microbiology · 2026
    Article
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hawraa ShahrourDepartment of Clinical Microbiology, RCSI Education & Research Centre, Beaumont Hospital, RCSI University of Medicine and Health Sciences, Dublin, Ireland.ORCID 0000-0002-4787-8262
Daniela Alves FerreiraDepartment of Clinical Microbiology, RCSI Education & Research Centre, Beaumont Hospital, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
Deirdre Fitzgerald-HughesDepartment of Clinical Microbiology, RCSI Education & Research Centre, Beaumont Hospital, RCSI University of Medicine and Health Sciences, Dublin, Ireland.
James P O'GaraDepartment of Microbiology, School of Biological and Chemical Sciences, University of Galway, Galway, Ireland.ORCID 0000-0003-3866-7161
Aidan CoffeyDepartment of Biological Sciences, Munster Technological University, Cork, Ireland.ORCID 0000-0003-4116-9913
Eoghan O'NeillDepartment of Clinical Microbiology, RCSI Education & Research Centre, Beaumont Hospital, RCSI University of Medicine and Health Sciences, Dublin, Ireland.ORCID 0000-0001-5222-8339

Funding

Health Research Board 19374A01
6 · The paper itself

Abstract

The pathogenesis of

Indexed as

Anti-Bacterial AgentsBacteriophagesBiofilmsEndopeptidasesStaphylococcal InfectionsStaphylococcus aureusWound InfectionCell LineHumansMicrobial Sensitivity TestsStaphylococcus PhagesAnti-Bacterial AgentsendolysinEndopeptidasesbiofilmCHAPK-SH3blysendolysinS. aureuswound infections

Identifiers

PMID40762578
PMCPMC12403842

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.