Evidence map›Paper›PMID 40762454›Full record

ArticleBiomarkers in medicine2025

Diagnostic value of lnc-RNAs TINCR, GC1 and AFAP1-AS1 in gastric cancer differentiation from healthy people.

Pouneh Pourfarzam, Mohammad Bagher Khademerfan, Ramin Shakeri, Reza Ghanbari, Asaad Azarnezhad

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Article in Biomarkers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Pouneh PourfarzamStudent Research Committee, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Mohammad Bagher KhademerfanCellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.
Ramin ShakeriDigestive Oncology Research Center, Digestive Disease Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Reza GhanbariGene Therapy Research Center, Digestive Diseases Research Institute, Shariati Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Asaad AzarnezhadCellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

AIMS AND

backgroundGastric cancer is a significant health challenge globally, necessitating the identification of novel biomarkers for improved diagnosis. Our study aimed to address this gap by investigating the diagnostic potential a set of long non-coding RNAs (lncRNAs) in gastric cancer patients compared to healthy controls. MATERIALS AND

methodsWe conducted a retrospective case-control analysis involving 256 participants, including 128 gastric cancer patients and 128 healthy individuals. Alongside the measurement of serum levels of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19.9), the plasma expression profiling of eight lnc-RNAs was performed in the selected samples.

resultsOur findings revealed significant alterations in CEA and CA19.9 levels in gastric cancer patients compared to controls (

conclusionOur study disclosed the diagnostic utility of plasma HOTIP, BANCR, ZFAS1, TINCR, GC1, and AFAP1-AS1 lncRNAs as appropriate diagnostic biomarkers for gastric cancer. The identification of dysregulated lncRNAs offers promising avenues for noninvasive diagnostic assessment in gastric cancer.

Indexed as

Biomarkers, TumorRNA, Long NoncodingStomach NeoplasmsAdultAgedCA-19-9 AntigenCarcinoembryonic AntigenCase-Control StudiesFemaleGene Expression Regulation, NeoplasticHumansMaleMiddle AgedRetrospective StudiesROC CurveAFAP1-AS1 long noncoding RNA, humanBiomarkers, TumorCA-19-9 AntigenCarcinoembryonic AntigenRNA, Long NoncodingTINCR lncRNA, humandiagnosisdiagnostic potentialGastric cancerlong non-coding RNAsnoninvasive biomarkersROC curve analysis

Identifiers

PMID40762454
PMCPMC12416196

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