ArticleCurrent protocols2025
Murine Models of Klebsiella pneumoniae Gastrointestinal Infection.
Article in Current protocols, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- Effect of Structural Trimming on the Therapeutic Efficacy of K2 Capsule Depolymerase'sAntibiotics (Basel, Switzerland) · 2026Article
- DksA-Dependent Stringent Stress Response Drives Virulence and Gastrointestinal Persistence ofbioRxiv : the preprint server for biology · 2026Article
- Article
- Murine Models of Klebsiella pneumoniae Gastrointestinal Infection.Current protocols · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Klebsiella pneumoniae (Kpn) is a Gram-negative opportunistic pathogen and a leading cause of hospital-acquired infections. The gastrointestinal (GI) tract serves as a critical site for Kpn colonization and a reservoir for host-to-host spread that primarily occurs through the fecal-oral route. The emergence of multidrug-resistant strains, coupled with virulence factors such as enhanced capsule production, presents significant challenges for clinical management and public health. Animal models-particularly murine models of GI colonization-are essential for advancing our understanding of Kpn pathogenesis, host-pathogen interactions, and for identifying therapeutic strategies. In this manuscript, we describe standardized protocols for studying Kpn GI colonization and systemic dissemination. These methods are designed to facilitate reproducibility and consistency across laboratories investigating Kpn colonization dynamics, dissemination routes, and immune evasion mechanisms. © 2025 The Author(s). Current Protocols published by Wiley Periodicals LLC. By providing detailed and optimized experimental approaches, this work aims to support the development of uniform methodologies for Kpn GI colonization and host response studies Basic Protocol 1: Murine model of Kpn gastrointestinal colonization via oral feeding Basic Protocol 2: Murine model of Kpn gastrointestinal colonization via gavage Basic Protocol 3: Murine model of Kpn intraperitoneal challenge Basic Protocol 4: Murine model of systemic Kpn infection via intravenous injection Basic Protocol 5: Kpn transmission studies following gastrointestinal colonization with intact microbiota Basic Protocol 6: Transmission studies of Kpn gastrointestinal colonization in antibiotic-pretreated mice Support Protocol 1: Preparation of Kpn inoculum Support Protocol 2: Preparation of mixed Kpn inoculum for competitive infection Support Protocol 3: Assessment of Kpn bacterial burden Support Protocol 4: Preparation of cecal filtrate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.