ReviewCancer science2025
Mechanisms Involved in Focal Adhesion Signaling Regulating Tumor Anoikis Resistance.
Review in Cancer science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Programmed cell death and metastatic evolution in breast cancer: the role of anoikis, necroptosis, and ferroptosis.Apoptosis : an international journal on programmed cell death · 2026Review
- Aerosol-Derived Graphene Oxide Nanofilm Suppresses Adhesion-Dependent Survival and Migration in Pancreatic Ductal Adenocarcinoma Cells.International journal of molecular sciences · 2026Article
- From Plastics to Prognosis:Diagnostics (Basel, Switzerland) · 2026Article
- Anoikis: To Die or Not to Die?International journal of molecular sciences · 2026Review
- Targeting MUC16 to Reverse Anoikis Resistance: A Promising Strategy for Metastatic Lung Adenocarcinoma Therapy.Journal of Cancer · 2026Article
- The tumor microenvironment as a key regulator of radiotherapy response.Frontiers in immunology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
Among the numerous malignant behaviors of tumors, metastasis plays a critical role in contributing to poor prognosis. Anoikis is a distinct form of apoptosis induced when cells detach from the extracellular matrix (ECM) or adhere to an improper ECM. It is a physiological obstacle to tumor cell metastasis. Anoikis resistance is considered to be a critical initial step in cancer cell metastasis. However, the mechanism by which tumor cells develop anoikis resistance is still unclear, in which the focal adhesion signaling pathway plays an important role. This review first outlines the composition of focal adhesion (FAs) multi-protein signaling complexes and then discusses the following three aspects: integrin expression changes of tumor cells, intracellular oxidative stress response, and FAs multi-protein signaling complex members activating downstream survival signaling pathways. The specific mechanisms of focal adhesion signaling pathways in tumor cell anoikis resistance and molecular characteristics of the anoikis resistance state are reviewed.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.