Evidence map›Paper›PMID 40762275›Full record

ArticleActa crystallographica. Section C, Structural chemistry2025

The cleavage of indinavir sulfate: synthesis and characterization of a cis-1-amino-2-indanol salt.

Tebogo M L Mokoto, Andreas Lemmerer, Yasien Sayed, Kgaugelo C Tapala, Itumeleng B Setshedi, Mark G Smith

Abstract read
In one paragraph

Article in Acta crystallographica. Section C, Structural chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Tebogo M L MokotoProtein Structure-Function Research Unit, School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.ORCID 0000-0001-7326-7118
Andreas LemmererMolecular Sciences Institute, School of Chemistry, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.ORCID 0000-0003-1569-2831
Yasien SayedProtein Structure-Function Research Unit, School of Molecular and Cell Biology, University of the Witwatersrand, Johannesburg, Gauteng, South Africa.ORCID 0000-0002-1781-2115
Kgaugelo C TapalaUniversity of South Africa, Department of Chemistry, Unisa Science Campus, Roodepoort, Gauteng, South Africa.ORCID 0000-0002-8530-9191
Itumeleng B SetshediUniversity of South Africa, Department of Life and Consumer Sciences, Unisa Science Campus, Roodepoort, Gauteng, South Africa.ORCID 0000-0001-8865-4735
Mark G SmithUniversity of South Africa, Department of Chemistry, Unisa Science Campus, Roodepoort, Gauteng, South Africa.ORCID 0000-0003-2553-2540

Funding

National Research Foundation CSUR23042597072
6 · The paper itself

Abstract

The HIV-1 protease inhibitor indinavir sulfate was cleaved via a one-pot reflux synthesis using 1-propanol, yielding the salt bis(2-hydroxy-2,3-dihydro-1H-inden-1-aminium) sulfate, 2C

Indexed as

chemical transformationscrystal structureindinavirsalt crystal structureslow evaporationsolvation crystallizationsurface analysisthermal analysis

Identifiers

PMID40762275
PMCPMC12406264

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.