ArticleNano letters2025
Attonewton Force Resolution Measurements with Silicon Nanospheres at the Thermal Noise Limit in Ambient-Temperature Liquids.
Article in Nano letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Precise force measurements are crucial for understanding fundamental physics or nanoscale interactions, such as those of molecular machines in biology. Optical tweezers are versatile force transducers for such measurements, enabling meticulous manipulation of small particles. However, achieving high-resolution, subfemtonewton force measurements under physiological conditions remains challenging due to thermal fluctuations and instrument noise. Here, we employed an ultrastable optical tweezers setup in an isolated environment with precise temperature control, which minimized instrumental noise and enabled prolonged, low-force measurements. We utilized water-suspended, high-refractive index silicon nanospheres for improved resolution and trapping stability. Our system achieved a force resolution of ≈60 aN, with a sensitivity of 2.7 fN Hz
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