ArticleHistopathology2025
Classification of prostatic adenocarcinoma as favourable/unfavourable histology has high interobserver agreement in prostate needle core biopsies.
Article in Histopathology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Correlation of unfavourable and favourable histology at radical prostatectomy with Decipher scores and freedom from biochemical recurrence.Histopathology · 2026Article
- Association between amide proton transfer-weighted imaging biomarkers and Gleason score in prostate cancer: a study on differential diagnosis from benign prostatic hyperplasia.Frontiers in oncology · 2026Article
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Authors and funding
11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
aimsA dichotomous classifier for prostatic adenocarcinoma, favourable and unfavourable histology, was recently proposed to optimize metastasis prediction. We evaluate interobserver agreement for its classification. METHODS AND
resultsFifty biopsies with prostatic adenocarcinoma were selected. One slide per biopsy was scanned using the Aperio AT2 scanner (20x) and viewed in Leica Web Viewer. Ten pathologists reviewed each slide after completing a training module. Biopsies were scored for Grade Group (1-5) and presence of unfavourable histology. Forty-one of 50 biopsies (82%) had unanimous consensus [13 (32%) unfavourable and 28 (68%) favourable], 47 (94%) for at least 9 of 10 reviewers, and 48 (96%) for at least 8 of 10 reviewers. Percent agreement for favourable/unfavourable classification was 94%, kappa = 0.88 (95% CI: 0.8, 0.96), and Gwet's AC1 coefficient = 0.90 (95% CI: 0.82, 0.97) [both P-value < 0.001]. Inter-rater agreement for Grade Group designation was evaluated in biopsies with 100% consensus. In the favourable consensus group (n = 28), kappa for Grade Group was 0.80 (95% CI: 0.62, 0.98) and Kendall's W was 0.83 (95% CI: 0.81, 0.89), with both P-value < 0.001. For the unfavourable consensus group (n = 13), kappa for Grade Group was 0.56 (95% CI: 0.36, 0.75) and Kendall's W was 0.78 (95% CI: 0.76, 0.85), with both P-value < 0.001.
conclusionsThe classification of prostatic adenocarcinoma as favourable/unfavourable histology has high interobserver agreement, even when learnt through a simple tutorial. GG designation was more variable. This provides evidence that the favourable/unfavourable classification could be utilized in routine practice given its ease of use.
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