Evidence map›Paper›PMID 40762219›Full record

ArticlePediatric emergency care2025

An Evaluation of Enteropathogen-Specific Disease Severity and Duration in Children With Acute Gastroenteritis.

Cindy G Roskind, David Schnadower, Alexander J Rogers, T Charles Casper, Phillip I Tarr, Adam C Levine, Seema R Bhatt, Serge Gouin, Prashant Mahajan, Cheryl Vance and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pediatric emergency care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Cindy G RoskindDepartment of Emergency Medicine, Columbia University, Vagelos College of Physicians & Surgeons, New York, NY.
David SchnadowerDivision of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Alexander J RogersDepartments of Emergency Medicine and Pediatrics, University of Michigan, Ann Arbor, MI.
T Charles CasperDepartment of Pediatrics, University of Utah, Salt Lake City, UT.
Phillip I TarrDepartment of Pediatrics, Division of Gastroenterology, Hepatology, & Nutrition, Washington University in St. Louis School of Medicine, St. Louis, MO.
Adam C LevineDepartment of Emergency Medicine, Rhode Island Hospital/Hasbro Children's Hospital and Brown University, Providence, RI.
Seema R BhattDivision of Emergency Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Serge GouinDepartments of Pediatric Emergency Medicine & Pediatrics, Université de Montréal, Montréal, Quebec, Canada.
Prashant MahajanDepartment of Pediatrics, Division of Emergency Medicine, Children's Hospital of Michigan Wayne State University, Detroit, MI.
Cheryl VanceDepartments of Pediatrics and Emergency Medicine, University of California, Davis, School of Medicine, Sacramento, CA.
Katrina F HurleyDepartment of Emergency Medicine, IWK Health Centre, Halifax, NS, Canada.
Jesse G NorrisDepartment of Pediatrics, University of Utah, Salt Lake City, UT.
Elizabeth C PowellDepartment of Pediatrics, Division of Emergency Medicine, Ann & Robert H. Lurie Children's Hospital of Chicago, Northwestern University Feinberg School of Medicine, Chicago, IL.
Ken J FarionDepartments of Pediatrics and Emergency Medicine, University of Ottawa, Ottawa, ON, Canada.
Robert E SapienDepartment of Emergency Medicine, University of New Mexico, Albuquerque, NM.
Karen J O'ConnellDepartment of Pediatrics, Division of Emergency Medicine, Children's National Health System, The George Washington School of Medicine and Health Sciences, Washington, DC.
Naveen PoonaiDepartments of Pediatrics, Internal Medicine, Epidemiology & Biostatistics, Schulich School of Medicine and Dentistry, London, Ontario, Canada.
Suzanne SchuhDepartment of Pediatrics, Division of Pediatric Emergency Medicine, The Hospital for Sick Children, SickKids Research Institute, University of Toronto, Toronto, Ontario, Canada.
Stephen B FreedmanSections of Pediatric Emergency Medicine and Gastroenterology, Departments of Pediatrics and Emergency Medicine, Alberta Children's Hospital, Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary, Calgary, AB, Canada.ORCID 0000-0003-2319-6192
Pediatric Emergency Research Canada (PERC) and the Pediatric Emergency Care Applied Research Network (PECARN)

Funding

Washington University DDRCC Supplemental Equipment RequestP30DK052574 · NIDDK · WASHINGTON UNIVERSITY · PI Nicholas O. Davidson · 2000 to 2026
$30.8M
Impact of Emergency Department Probiotic Treatment of Pediatric GastroenteritisR01HD071915 · NICHD · WASHINGTON UNIVERSITY · PI FREEDMAN, STEPHEN BRADLEY, SCHNADOWER, DAVID · 2014 to 2018
$3.6M
NICHD NIH HHS R01 HD071915NIDDK NIH HHS P30 DK052574
6 · The paper itself

Abstract

objectivesOur primary objectives were to describe pathogen-specific symptom severity and duration in a prospective cohort study of children with acute gastroenteritis (AGE). Our secondary objective was to quantify health care resource utilization.

methodsThis secondary analysis of 2 trials included children aged 3 to 48 months with AGE. Children were eligible if they had ≥3 watery stools in the preceding 24 hours and were brought to the Emergency Department. Disease severity was quantified by frequency and duration of vomiting and diarrhea, and the Modified Vesikari Scale score. We used descriptive statistics to summarize severity and regression models to identify associations between pathogen type and outcomes.

resultsIn total, 1565 trial participants had pathogen testing performed and completed follow-up. Viral pathogens were identified in 47.9% (749/1565) and bacterial pathogens in 5.9% (92/1565). Norovirus (322/1565; 20.6%) was the most frequently identified pathogen. Diarrhea duration was greatest (median 160h, IQR: 98, 216) for children with Salmonella . Vomiting (aOR: 11.02; 95% CI: 7.47, 16.26) occurred more commonly in children with viruses compared with bacteria. The mean duration of diarrhea was shorter for viruses compared with bacteria (aIRR: 0.81, 95% CI: 0.68, 0.96). Mean MVS scores were higher in children with viruses compared with those with bacteria (coefficient: 1.64, 95% CI: 0.46, 2.82).

conclusionsWe describe the clinical course of viral and bacterial pathogens. Although statistically significant, differences in symptom severity across pathogens were not clinically meaningful for distinguishing between them based on symptoms alone.

Indexed as

GastroenteritisAcute DiseaseChild, PreschoolDiarrheaEmergency Service, HospitalFemaleHumansInfantMaleProspective StudiesSeverity of Illness IndexTime FactorsVomitingacute gastroenteritisdiarrheaModified Vesikari Scalevomiting

Identifiers

PMID40762219
PMCPMC13515014

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.