GuidelineJournal of cosmetic dermatology2025
Anatomical Guideline for Retrobulbar Hyaluronidase Injection.
Guideline in Journal of cosmetic dermatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Anatomical Guideline for Retrobulbar Hyaluronidase Injection.Journal of cosmetic dermatology · 2025Guideline
- Hyaluronidase Use in Aesthetic Medicine: Formulations, Safety, and Clinical Practice.Journal of clinical medicine · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundVision loss following cosmetic filler injections is a rare but devastating complication resulting from inadvertent intravascular embolization, most often affecting the ophthalmic artery. Retrobulbar hyaluronidase injection has been proposed as an emergency intervention, yet anatomical guidelines for its administration remain poorly defined.
objectiveTo propose an anatomically informed protocol for safe and effective retrobulbar hyaluronidase injection in cases of filler-induced central retinal artery occlusion.
methodsCadaveric dissections and micro-CT imaging were used to map orbital anatomy, focusing on the spatial relationship between the optic nerve, ophthalmic artery, and adjacent structures. The inferolateral quadrant was identified as the safest trajectory for retrobulbar injection, minimizing risk to ocular muscles and nerves.
resultsThe optimal needle trajectory was from the inferolateral orbital rim toward the superior medial quadrant, avoiding critical neurovascular structures. A 35 mm, 22-23G needle was deemed appropriate for reaching the retrobulbar space while minimizing the risk of globe perforation.
conclusionThis study provides a standardized anatomical approach for retrobulbar hyaluronidase injection, aiming to improve safety and potentially restore perfusion in acute filler-induced visual loss. Clinical implementation should proceed with caution and in multidisciplinary settings.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.