Evidence map›Paper›PMID 40762185›Full record

ArticleJournal of the science of food and agriculture2025

Exploring gastroprotective effect and mechanisms of epigallocatechin gallate-impregnated black garlic in acidic ethanol-induced gastric ulcer model mice.

Ming-Shiun Tsai, Gunn-Guang Liou, Chang-Wei Hsieh, Jiunn-Wang Liao, Pin-Yen Lai, Chao-Kai Chang, Wan-Jou Lee, Sue-Hong Wang

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Article in Journal of the science of food and agriculture, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Ming-Shiun TsaiDepartment of Medicinal Botanicals and Foods on Health Application, Da-Yeh University, Changhua, Taiwan.
Gunn-Guang LiouOffice of Research and Development, College of Medicine, National Taiwan University, Taipei, Taiwan.
Chang-Wei HsiehDepartment of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan.ORCID https://orcid.org/0000-0002-0533-9762
Jiunn-Wang LiaoGraduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taichung, Taiwan.
Pin-Yen LaiDepartment of Biomedical Sciences, Chung Shan Medical University, Taichung, Taiwan.
Chao-Kai ChangDepartment of Food Science and Biotechnology, National Chung Hsing University, Taichung, Taiwan.
Wan-Jou LeeDepartment of Biomedical Sciences, Chung Shan Medical University, Taichung, Taiwan.
Sue-Hong WangDepartment of Biomedical Sciences, Chung Shan Medical University, Taichung, Taiwan.ORCID https://orcid.org/0000-0001-7024-1676

Funding

Intramural Research Grant of Chung Shan Medical University CSMU-INT-113-15Ministry of Science and Technology of Taiwan MOST 107-2628-B-005-002-MY3Ministry of Science and Technology of Taiwan MOST 110-2320-B-040-008Ministry of Science and Technology, the Ministry of Education
6 · The paper itself

Abstract

backgroundPeptic ulcers, particularly gastric ulcers (GUs), are multifactorial disorders with unclear mechanisms. Black garlic (BG) has shown gastroprotective effects. This study evaluated the effects of BG and epigallocatechin gallate-impregnated BG (EG) in acidic ethanol (AE)-induced GU model mice. Mice were pretreated with BG or EG (50-200 mg/kg) for 7 days before ulcer induction. Oral acute toxicity evaluations for BG and EG were also conducted.

resultsOral acute toxicity evaluations showed elevated serum renal function indices at 5 g/kg of BG and 10 g/kg of EG but without histopathological liver or kidney damage. Both BG and EG pretreatments reduced ulcer indices, with EG offering stronger and significant protection. EG pretreatments also showed higher gastric mucosal accumulations. They significantly decreased AE-induced malondialdehyde levels and restored glutathione, superoxide dismutase, and catalase. AE-induced serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), interleukin-1 beta (IL-1β), as well as gastric transcript levels of TNF-α, IL-6, IL-1β, cyclooxygenase-2, inducible nitric oxide synthase, and myeloperoxidase, were suppressed. EG further reduced AE-induced phosphorylations of extracellular signal-regulated kinase, c-jun-N-terminal kinase, p38, nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), and inhibitor of κB.

conclusionEG2 showed stronger gastroprotective activity than BG by modulating oxidative stress, inflammatory response, and mitogen-activated protein kinase (MAPK)/NF-κB signaling pathways. This study supports the application of EG as a value-added functional food ingredient for GU prevention. © 2025 The Author(s). Journal of the Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

Indexed as

Anti-Ulcer AgentsCatechinGarlicPlant ExtractsStomach UlcerAnimalsCatalaseCyclooxygenase 2Disease Models, AnimalEthanolGastric MucosaGlutathioneHumansInterleukin-1betaInterleukin-6MaleAnti-Ulcer AgentsCatalaseCatechinCyclooxygenase 2epigallocatechin gallateEthanolGlutathioneInterleukin-1betaInterleukin-6MalondialdehydeNF-kappa BNitric Oxide Synthase Type IIPlant ExtractsSuperoxide DismutaseTumor Necrosis Factor-alphaanti‐inflammatoryantioxidantblack garlic from different processesgastroprotectionMAPK signaling pathwayNF‐κB signaling pathway

Identifiers

PMID40762185
PMCPMC12595404

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.