ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025
Performance of computed tomography and magnetic resonance morphometry in evaluating brain atrophy in Down syndrome.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Performance of computed tomography and magnetic resonance morphometry in evaluating brain atrophy in Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
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10 authors.
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Abstract
backgroundTo compare the performance of computed tomography (CT) with that of magnetic resonance imaging (MRI) in assessing brain atrophy in Down syndrome (DS).
methodsRetrospective comparison of CT-derived gray and white matter measurements with those obtained by MRI using voxel-based morphometry (VBM) in adults with DS who underwent both scanning modalities with a maximum interval of 1 year. The concordance of both tests was compared across sample quartiles.
resultsEleven of 23 participants had some degree of cognitive decline. When comparing VBM outputs of both imaging techniques, an overlap of voxels negatively correlated with dementia severity was observed in the right temporal lobe. Observed agreement was 92.3% (quadratic-weighted kappa index 0.71) for both gray and white matter. DISCUSSION: CT and MRI analyses showed a similar decrease in brain volume as cognitive decline increased. Our results highlight the potential use of CT in computational neuroanatomy studies of DS. HIGHLIGHTS: Voxel-based morphometry shows that computed tomography (CT) and magnetic resonance imaging (MRI) yield similar brain atrophy patterns in DS. Strong agreement (kappa index 0.71) was found between CT and MRI assessments. CT-identified right temporal lobe volume loss linked to cognitive decline in DS. CT offers a practical, accessible alternative to MRI for brain imaging in DS. Artificial intelligence-based CT analysis enhances neuroimaging for DS with reduced motion issues.
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