Evidence map›Paper›PMID 40762106›Full record

ArticleEuropean journal of immunology2025

Generation of Regulatory T Cells From Human Memory CD4

Jiajun He, Kristy Ou, Michael Schmueck-Henneresse, Edgar Specker, Jérôme Paul, Marc Nazare, Jens Peter von Kries, Julia K Polansky, Alf Hamann, Stefan Frischbutter

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jiajun HeInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.
Kristy OuBIH Center for Regenerative Therapies (BCRT), T Cell Epigenetics, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.
Michael Schmueck-HenneresseBIH Center for Regenerative Therapies (BCRT), Berlin Institute of Health (BIH) At Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0001-5964-9179
Edgar SpeckerChemical Biology Platform, Leibniz-Forschungsinstitut Für Molekulare Pharmakologie (FMP), Berlin-Buch, Germany.
Jérôme PaulChemical Biology Platform, Leibniz-Forschungsinstitut Für Molekulare Pharmakologie (FMP), Berlin-Buch, Germany.
Marc NazareChemical Biology Platform, Leibniz-Forschungsinstitut Für Molekulare Pharmakologie (FMP), Berlin-Buch, Germany.ORCID 0000-0002-1602-2330
Jens Peter von KriesChemical Biology Platform, Leibniz-Forschungsinstitut Für Molekulare Pharmakologie (FMP), Berlin-Buch, Germany.
Julia K PolanskyBIH Center for Regenerative Therapies (BCRT), T Cell Epigenetics, Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0003-4727-2540
Alf HamannDepartment of Rheumatology and Clinical Immunology, Charité - Universitätsmedizin Berlin, Berlin, Germany.
Stefan FrischbutterInstitute of Allergology, Charité - Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany.ORCID 0000-0003-3971-7343

Funding

European Research Council ERC Starting grant 'EpiTune'European Research Council No 803992 to JKPSPARK-BIH program from the Berlin Institute of Health at Charité - Universitätsmedizin Berlin
6 · The paper itself

Abstract

Regulatory T cells are indispensable for immune homeostasis and tolerance to self-antigens and allergens. The imbalance between immune responses and tolerance causes allergic and autoimmune diseases. A promising therapeutic strategy is to support immune tolerance by converting conventional T cells into suppressive regulatory T cells with small molecular weight compounds, an area that is underexplored. Here, we report the identification, characterization, and validation of a novel quinoxaline derivative (IFA005) that converts human memory CD4

Indexed as

CD4-Positive T-LymphocytesMemory T CellsT-Lymphocytes, Regulatorybeta CateninCells, CulturedForkhead Transcription FactorsGlycogen Synthase Kinase 3 betaHumansImmune ToleranceImmunologic MemoryMembrane ProteinsUp-RegulationWnt Signaling Pathwaybeta CateninForkhead Transcription FactorsFOXP3 protein, humanGlycogen Synthase Kinase 3 betaLRRC32 protein, humanMembrane Proteins

Identifiers

PMID40762106
PMCPMC12322872

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.