Synthetic, Computational, and Experimental Studies of a Class 3 Atropisomeric α-Naphthyl Tropone.

Nana B Agyemang, Jordan Nafie, Mark R Biscoe, Ryan P Murelli

Abstract read

In one paragraph

Article in The Journal of organic chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nana B AgyemangPhD Program in Chemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States.

Jordan NafieBiotools, Inc., 17546 Bee Line Highway, Jupiter, Florida 33478, United States.

Mark R BiscoePhD Program in Chemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States.ORCID 0000-0003-1257-6288

Ryan P MurelliPhD Program in Chemistry, The Graduate Center of the City University of New York, New York, New York 10016, United States.ORCID 0000-0002-4247-3936

Funding

G-RISE: Graduate Research Initiative for Student Advancement at The City College of New YorkT32GM136499 · NIGMS · CITY COLLEGE OF NEW YORK · PI RUTH E. STARK · 2020 to 2026

$4.9M

Development and Exploitation of New Synthetic Strategies for TropolonesSC1GM111158 · NIGMS · BROOKLYN COLLEGE · PI MURELLI, RYAN · 2015 to 2023

$3.1M

Stereospecific Cross-Coupling Reactions as a Tool for Three Dimensional Molecular DiversificationR01GM131079 · NIGMS · CITY COLLEGE OF NEW YORK · PI Mark Roger Biscoe · 2018 to 2026

$2.5M

NIGMS NIH HHS R01 GM131079NIGMS NIH HHS SC1 GM111158NIGMS NIH HHS T32 GM136499

6 · The paper itself

Abstract

Atropisomerism is a stereochemical phenomenon that results from high configurational stability of chiral axes and is an important structural element in many functional molecules. Thus, understanding how different structural features can influence the stability of chiral axes can be an important consideration for molecular design. Recent studies have demonstrated that certain tropone-based chiral axes are significantly more stable than those of related benzenoids, likely a result of their relatively smaller external bond angles. The following manuscript explores this phenomenon through computational and experimental studies on a simple, class 3 atropisomeric α-naphthyl-substituted tropone (ΔG

Identifiers

PMID40762049

DOI10.1021/acs.joc.5c00992

PMCPMC12362610

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.