ArticleOncology letters2025
Acute myeloid leukemia with plasmacytoid dendritic cell proliferation: A case report and literature review.
Article in Oncology letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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13 authors.
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Abstract
The present study describes a rare case of plasmacytoid dendritic cell-associated acute myeloid leukemia (pDC-AML). A 70-year-old male patient was diagnosed with pDC-AML and underwent induction chemotherapy using the venetoclax + azacitidine (VA) regimen. After 3 weeks of treatment, bone marrow examination indicated a morphologic leukemia-free state (MLFS); however, the patient experienced persistent cytopenia, which was further complicated by severe pneumonia and gastrointestinal bleeding, both of which improved following treatment. After 3 weeks in MLFS, bone marrow morphology and minimal residual disease analysis revealed a relapse of leukemia. The patient subsequently underwent treatment with selinexor in conjunction with the VA regimen; however, due to severe thrombocytopenia, the family decided to discontinue further treatment. The patient subsequently succumbed shortly after discharge. pDC-AML is an extremely rare disease characterized by low complete remission rates and a poor prognosis. While the VA regimen demonstrates rapid efficacy and favorable safety in elderly patients, especially those unable to tolerate intensive chemotherapy, the risk of relapse remains substantial. CD123-targeted therapies may present potential new therapeutic options for this disease. Improving remission rates and extending survival in patients with pDC-AML remain pressing clinical challenges.
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