Evidence map›Paper›PMID 40761894›Full record

ArticleTherapeutic advances in infectious disease

Caspofungin versus anidulafungin in patients with invasive candidiasis: a retrospective study with propensity-score-matched analysis.

Reem Hasan Elajez, Dana Bakdach, Sara Al Balushi, Ahmed Zaqout, Rand Alattar, Tasneem Abdallah, Waleed Awouda, Godwin Wilson, Walid Al-Wali, Emad Ibrahim and 1 more

Abstract read
In one paragraph

Article in Therapeutic advances in infectious disease. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Clinical Outcomes of Micafungin and Anidulafungin inJournal of fungi (Basel, Switzerland) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Reem Hasan ElajezPharmacy Department, Hamad General Hospital, Hamad Medical Corporation, P.O. Box 3050, Doha, Qatar.ORCID https://orcid.org/0000-0001-7824-3203
Dana BakdachPharmacy Department, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar.
Sara Al BalushiEpidemiology Section, Communicable Disease Centre, Hamad Medical Corporation, Doha, Qatar.
Ahmed ZaqoutDivision of Infectious Diseases, Department of Medicine, Communicable Disease Centre, Hamad Medical Corporation, Doha, Qatar.
Rand AlattarPharmacy Department, Communicable Disease Center, Hamad Medical Corporation, Doha, Qatar.
Tasneem AbdallahDivision of Infectious Diseases, Department of Medicine, Communicable Disease Centre, Hamad Medical Corporation, Doha, Qatar.
Waleed AwoudaDivision of Infectious Diseases, Department of Medicine, Communicable Disease Centre, Hamad Medical Corporation, Doha, Qatar.
Godwin WilsonDepartment of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar.
Walid Al-WaliDepartment of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar.
Emad IbrahimDepartment of Laboratory Medicine and Pathology, Hamad Medical Corporation, Doha, Qatar.
Hussam AlsoubDivision of Infectious Diseases, Department of Medicine, Communicable Disease Centre, Hamad Medical Corporation, Doha, Qatar.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Echinocandins are recommended as an initial treatment for invasive candidiasis. Although safety and efficacy profiles of both anidulafungin and caspofungin are well established, direct head-to-head comparisons have not been reported before. Objective: Compare efficacy and safety of anidulafungin versus caspofungin among patients with invasive candidiasis. Design: Retrospective observational study. Methods: Adult patients with invasive candidiasis who were treated with either anidulafungin or caspofungin for ⩾5 days were retrospectively reviewed over a period of 6 years. The primary endpoint was global response, defined as clinical and microbiological success at the end of treatment duration. Results: A total of 223 patients who received either anidulafungin ( Conclusion: Our data suggest that anidulafungin and caspofungin have comparable global response among patients with invasive candidiasis. Additionally, both studied echinocandins showed no significant difference in 90-day all-cause mortality. However, due to the limited sample size, larger studies are needed to confirm these results.

Indexed as

anidulafungincaspofungininvasive candidiasis

Identifiers

PMID40761894
PMCPMC12319202

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.