ArticleFrontiers in pediatrics2025
Benzoyl peroxide in the treatment of acne: are there potential health concerns?
Article in Frontiers in pediatrics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- An adjunctive dermocosmetic regimen improves clinical outcomes and tolerability in Japanese patients on topical acne therapy: A real-world observational study.The Journal of international medical research · 2026Observational
- Blue Light-Mediated Nitric Oxide-Releasing Formulation for the Multimodal Treatment of Acne Vulgaris.Advanced healthcare materials · 2026Article
- Rebalancing the Skin: The Microbiome, Acne Pathogenesis, and the Future of Natural and Synthetic Therapies.Molecules (Basel, Switzerland) · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Benzoyl peroxide is a widely used and effective topical treatment for acne vulgaris, particularly in pediatric and adolescent populations. Despite its established safety profile, recent concerns emerged regarding its potential to decompose into benzene, a known carcinogen, under specific environmental conditions, like elevated temperatures and exposure to ultraviolet radiation. In this paper we review the management of acne vulgaris in pediatric patients, examine the evidence supporting benzoyl peroxide use and explore the recent studies evaluating the association between benzoyl peroxide use and malignancy risk. While initial reports raised alarm over benzene formation, subsequent investigations have not demonstrated an increased risk of hematologic malignancies. Here, we assess the strengths and limitations of existing evidence and identify future research priorities. Additionally, we provide recommendations for the safe and evidence-based use of benzoyl peroxide in pediatric acne treatment.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.