SynthesisFrontiers in medicine2025
Effectiveness of dietary supplements for skin photoaging in healthy adults: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07516756 (Impact of Oral Supplementation of Specific Bioactive Collagen Peptides on Human Skin Physiology), which is not on this map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Oral Supplementation of Specific Bioactive Collagen Peptides on Human Skin Physiology: A Randomized, Double-Blind, Placebo-Controlled Trial
Who cites it
4 citing papers in PubMed.
- Skin Resilience and Biological Adaptability: Current Clinical Evidence on Micronutrients and Bioactive Compounds.Biomedicines · 2026Review
- Edible Fungi and Skin Redox Homeostasis: Bioactive Diversity, Processing, Oral Exposure, and Evidence Gaps.Antioxidants (Basel, Switzerland) · 2026Review
- Microbiome-Directed Bioactive Strategies in Skin Aging: Mechanistic Insights and Precision Nanocarrier Delivery Approaches.Molecules (Basel, Switzerland) · 2026Review
- Molecular mechanisms of traditional Chinese medicine in skin aging: a narrative review.Frontiers in pharmacology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The dietary supplement industry offers a wide range of orally consumed products that claim to combat skin photoaging, however, there is a lack of research on the proof of safety and effectiveness of dietary supplements in anti-skin photoaging. To further confirm their safety and efficacy, this article provides a detailed review and meta-analysis. Methods: Four databases, including PubMed, Embase, Web of Science, and the Cochrane Library (Central Database), were searched for relevant literature up to October 2024. A total of forty English-language randomized controlled trials (RCTs) investigating the relationship between dietary supplements and skin photoaging were screened for an in-depth review and meta-analysis. Results: Collagen, flavanols, and other polyphenol supplements have been found to alleviate skin photoaging and increase MED or overall skin elasticity (R2) when compared to a placebo. However, hyaluronic acid, lycopene, and carotenoids did not show any significant benefits in improving skin photoaging or MED/R2. Due to inconsistent findings and limited research, the effects of dietary supplements on skin photoaging could not be determined in randomized controlled trials with two or fewer studies. It is important to note that, during the study period (typically ≤ 24 weeks), all orally administered dietary supplements were found to be safe. Conclusion: Oral dietary supplements, such as collagen, flavanols, and polyphenols, have demonstrated effectiveness in addressing skin photoaging. However, there is currently insufficient evidence to support the recommendation of other dietary supplements, such as astaxanthin, for the treatment of skin photoaging. This research serves as an initial step in exploring the benefits of dietary supplements in combating skin photoaging. It underscores the need for more focused studies to further investigate the effects of dietary supplements on skin photoaging and gather additional evidence supporting their efficacy. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42023472473, identifier CRD42023472473.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.