SynthesisFrontiers in medicine2025
Comparison of single-spin to double-spin platelet-rich plasma centrifugation methods in the treatment of androgenic alopecia: a systematic review and meta-analysis of randomized controlled trials.
Synthesis in Frontiers in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Analysis of platelet rich plasma preparations by routine centrifuge versus two commercially available standardized centrifuges.Pakistan journal of medical sciences · 2026Article
- Optimized Platelet-Rich Plasma Preparations for a Consistently High Platelet Capture Rate, Bioformulation Flexibility, and Red Blood Cell Reduction Using a Single-Spin Device.Bioengineering (Basel, Switzerland) · 2026Article
- Quantitative Imaging Biomarkers of PRP-Induced Tendon Remodelling in Chronic Tendinopathy: Review and Single-Centre Experience with Ultrasound Radiomics and MRI T2 Profiling.Diagnostics (Basel, Switzerland) · 2026Review
- Anticoagulant-free preparation of autologous platelet-rich plasma (PRP) / fluid platelet-rich fibrin (f-PRF): a pre-clinical comparative performance study.Frontiers in pharmacology · 2026Article
- Comparative Evaluation of Buffy Coat-Derived and Apheresis Platelet-Rich Plasma in the Treatment of Androgenetic Alopecia: Laboratory and Clinical Insights.Clinical, cosmetic and investigational dermatology · 2026Article
- Advances in Anti-aging Procedures: A Comprehensive Review of Surgical and Non-surgical Rejuvenation Techniques.Cureus · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Androgenic alopecia (AGA) is the most common hair loss disease, caused by a combination of genetic factors and hormonal imbalances. Platelet-rich plasma (PRP) therapy has gained significant recognition in treating AGA, but optimal treatment protocol regarding centrifugation techniques has yet to reach a standardized consensus. We aim to conduct a systematic review and meta-analysis of randomized controlled trials (RCTs) to compare the efficacy of single-spin versus double-spin centrifugation protocols for PRP in patients with AGA. Methods: We searched PubMed, Embase, and Cochrane for RCTs comparing single-spin to double-spin PRP in AGA patients. The primary endpoint was the final platelets count after centrifugation. Secondary endpoints included improvement in hair density, as well as terminal and vellus hair rate. Statistical analysis was performed using RStudio software. Heterogeneity was assessed with Results: We included 90 participants with AGA from three RCTs. The pooled mean difference (MD) for platelets concentration was 66.14 in single-spin compared to double-spin PRP (95% CI: -372.96 to 505.25; Conclusion: Our study suggests that single-spin PRP centrifugation is better in treating AGA patients compared to double-spin PRP. Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD42025643296, identifier CRD42025643296.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.