ArticleInternational journal of pharmaceutics: X2025
Comparative study of β-cyclodextrin derivatives with amlodipine inclusion complexes for enhanced solubility, drug release, and anticancer activity.
Article in International journal of pharmaceutics: X, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Development, Validation and Application of an RP-HPLC Method for the Determination of Reproxalap in Cyclodextrin Inclusion Complexes and an In Situ Ocular Hydrogel.Pharmaceutics · 2026Article
- Chitosan/β-cyclodextrin nanocarriers enhance 5-fluorouracil efficacy against colorectal cancer via pH-responsive release and apoptosis modulation.Scientific reports · 2026Article
- Modulation of Drug Release in Anticancer Therapy: Recent Advances, Challenges, and Emerging Drug Delivery Platforms.Pharmaceutics · 2026Review
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7 authors.
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Abstract
Amlodipine (AMD), a calcium channel blocker, has become a viable anticancer treatment because of its biological properties. However, its poor water solubility and low bioavailability hinder its physiological activities and therapeutic applications when administered orally. In this study, inclusion complexes (ICs) of AMD with pure cyclodextrins (CDs) and three different CD derivatives, namely hydroxypropyl β-cyclodextrin (HD), methyl-β-cyclodextrin (MD), and sulfobutylether-β-cyclodextrin (SD), were prepared, and their physicochemical and biological properties were compared. The enhanced solubility of AMD:CD IC formation in aqueous media was measured using UV-Vis and fluorescence spectroscopy, and the binding constants were calculated using the Benesi-Hildebrand method. In addition, phase solubility studies confirmed the formation of 1:1 ICs, which followed an A
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