ArticleFrontiers in endocrinology2025
Association between triglyceride glucose-body mass index and acute kidney injury and renal replacement therapy in critically ill patients with sepsis: analysis of the MIMIC-IV database.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Development of a multivariable clinical prediction model for acute kidney injury after valve replacement surgery: incremental value of the triglyceride-glucose body mass index.Journal of thoracic disease · 2026Article
- The joint association of insulin resistance index and neutrophil percentage to albumin ratio with acute kidney injury after orthopedic surgery: a retrospective cohort study.Frontiers in nutrition · 2026Article
- U-shaped association between triglyceride-glucose index and acute kidney injury in critically ill children with cardiac diseases.Frontiers in endocrinology · 2025Article
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5 authors.
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Abstract
Background: Previous studies have linked kidney damage to insulin resistance (IR), yet the association between triglyceride glucose-body mass (TyG-BMI) index, a reliable marker of IR, and acute kidney injury (AKI) remains unclear. Methods: Patient data were collected from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. AKI was set as the primary endpoint, and renal replacement therapy (RRT) was set as the secondary endpoint to represent the progression of AKI. TyG-BMI index and study endpoints were analyzed using Cox regression and restricted cubic spline (RCS) analyses. Results: A total of 1,117 patients with sepsis were enrolled, of whom 559 (50.0%) developed AKI. The result of Cox regression revealed that the TyG-BMI index was closely related to AKI ( Conclusions: For critically ill patients with sepsis, an elevated TyG-BMI index implies a possible increased risk of AKI. The TyG-BMI index has the potential to be a valuable predictor.
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