SynthesisFrontiers in sports and active living2025
Assembly and activation of the NLRP3 inflammasome and cytokine quantification in response to exercise in adults with different metabolic conditions: a systematic review.
Synthesis in Frontiers in sports and active living, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Taoren Honghua Jian Regulate NLRP3 Inflammasome of Coronary Artery Disease Patients: A Multi-Center, Double-Blind, Randomized Controlled Trial.Vascular health and risk management · 2026Trial
- High-load resistance training and FSHD: harmful mixture or a silver bullet combination?Journal of neurology · 2026Review
- Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review).International journal of molecular medicine · 2026Review
- Exercise-Induced Exerkines: Multi-Nodal Suppression of the NLRP3 Inflammasome and Translational Potential.Medicinal research reviews · 2026Review
- Exercise-specific post-translational modification signatures: unveiling precise regulatory mechanisms of molecular exercise language and cellular adaptation.Frontiers in sports and active living · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The NLRP3 inflammasome is a molecular structure involved in inflammation and innate immune response, its overexpression has been associated with the development of several diseases. Physical exercise plays an important role in regulating systemic inflammation, however different types of exercise seem to have a different effect in the regulation of the NLRP3 inflammasome. Objective: To provide updated information related to the effect of different types and training durations of exercise on NLRP3 inflammasome complex, IL-1β-IL-18 cytokines quantification in adults with different metabolic conditions. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) methodology for manuscript research and preparation was followed using PubMed, Science Direct, SpringerLink, Scopus and Google Scholar databases for literature review. Out of 1,514 articles identified, only 11 articles fulfilled the inclusion criteria. Results: Moderate-intensity aerobic exercise and moderate resistance exercise seems to significantly decreased concentrations of the cytokine IL-1β, NLRP3 protein and caspase-1, as well as Conclusion: Resistance, aerobic and combined exercise (≥8 weeks) were linked to downregulated key NLRP3 inflammasome components across diverse populations. These results support exercise as a safe and effective strategy to modulate NLRP3-driven inflammation. Notably, evidence suggest that resistance and combined modalities showed superior efficacy in reducing both gene and cytokine levels. This positions structured exercise as a valuable tool in managing chronic low-grade inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.