Evidence map›Paper›PMID 40761793›Full record

ArticleFrontiers in immunology2025

Macrophage transfer promotes intestinal mucosal healing by encouraging transit-amplifying cell expansion in mice.

Dong Su Kang, Young Min Song, Yeon Ji Park, Hyeon Jong Jeong, Jung Joo Hong, Seung Hyeok Seok, Yi Rang Na

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dong Su KangTranslational Immunology Lab, Department of Transdisciplinary Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Young Min SongTranslational Immunology Lab, Department of Transdisciplinary Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Yeon Ji ParkTranslational Immunology Lab, Department of Transdisciplinary Medicine, Seoul National University Hospital, Seoul, Republic of Korea.
Hyeon Jong JeongMacrophage Lab, Department of Microbiology and Immunology, and Institute of Endemic Disease, Seoul National University College of Medicine, Seoul, Republic of Korea.
Jung Joo HongNational Primate Research Center, Korea Research Institute of Bioscience and Biotechnology, Cheongju, Republic of Korea.
Seung Hyeok SeokCancer Research Institute, Seoul National University, Seoul, Republic of Korea.
Yi Rang NaTranslational Immunology Lab, Department of Transdisciplinary Medicine, Seoul National University Hospital, Seoul, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular therapy, including stem cell injections, has been proved to be therapeutic for patients with inflammatory bowel disease (IBDs), showing promising outcomes of disease progression. However, challenges of stem cell therapy remain, such as Crohn's disease with complex fistula, thus limiting its use and requiring another cellular therapy target for efficacy. Alternatively, macrophages have been reported to enhance recovery of damaged intestinal epithelial barriers during resolution of IBDs; thus, utilizing macrophage as a therapeutic strategy was hypothesized. In this study, we compared the regenerative capacity of wild-type and

Indexed as

ColitisIntestinal MucosaMacrophagesWound HealingAnimalsCell ProliferationDisease Models, AnimalInflammatory Bowel DiseasesMiceMice, Inbred C57BLMice, KnockoutTumor Necrosis Factor-alphaTumor Necrosis Factor-alphacell-therapyDSS-induced Colitis modelIMCmacrophagemucosal immunologyregeneration

Identifiers

PMID40761793
PMCPMC12318747

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.