Evidence map›Paper›PMID 40761766›Full record

ArticleOxidative medicine and cellular longevity2025

Sheelu Monga, Samantha Flores, Maria Pilar Blasco-Conesa, Syed M Rahman, Brian Noh, Pedram Peesh, Bhanu Priya Ganesh, Sean P Marrelli, Louise D McCullough, Jose Felix Moruno-Manchon

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sheelu MongaDepartment of Neurology, McGovern Medical School at the University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston 77030, Texas, USA.
Samantha FloresDepartment of Neurology, McGovern Medical School at the University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston 77030, Texas, USA.
Maria Pilar Blasco-ConesaDepartment of Neurology, McGovern Medical School at the University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston 77030, Texas, USA.ORCID https://orcid.org/0000-0002-0700-4907
Syed M RahmanDepartment of Neurology, McGovern Medical School at the University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston 77030, Texas, USA.
Brian NohDepartment of Neurology, McGovern Medical School at the University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston 77030, Texas, USA.
Pedram PeeshDepartment of Neurology, McGovern Medical School at the University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston 77030, Texas, USA.
Bhanu Priya GaneshDepartment of Neurology, McGovern Medical School at the University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston 77030, Texas, USA.
Sean P MarrelliDepartment of Neurology, McGovern Medical School at the University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston 77030, Texas, USA.ORCID https://orcid.org/0000-0001-8476-4785
Louise D McCulloughDepartment of Neurology, McGovern Medical School at the University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston 77030, Texas, USA.
Jose Felix Moruno-ManchonDepartment of Neurology, McGovern Medical School at the University of Texas Health Science Center at Houston, 6431 Fannin Street, Houston 77030, Texas, USA.ORCID https://orcid.org/0000-0002-2139-6134

Funding

Sex Differences in Inflammation Across the LifespanR35NS132265 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Louise D. McCullough · 2023 to 2026
$4.5M
CCN1-induced Senescence in the Cerebral VasculatureR21AG075750 · NIA · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI MORUNO MANCHON, JOSE FELIX · 2022 to 2023
$429k
NIA NIH HHS R21 AG075750NINDS NIH HHS R35 NS132265
6 · The paper itself

Abstract

As we age, cerebral endothelial cells (CECs) are less efficient in maintaining genome integrity and accumulate DNA damage. DNA damage in the brain endothelium can lead to the impairment of the blood-brain barrier (BBB), which is a major factor in brain dysfunction and dementia. Thus, identifying factors that regulate DNA repair in the brain endothelium can prevent brain dysfunction associated with aging. E2F1 is a transcription factor that regulates the expression of genes associated with DNA repair, among other functions. We hypothesize that E2F1 is downregulated in the brain vasculature of mice with aging and that E2F1 upregulation can improve cognitive function. We found that in the brain endothelium, E2F1 was significantly less phosphorylated, which is associated with its transcriptional activity, in the brain vasculature of aged mice and cultured CEC derived from aged mice compared with those from young mice. We found that

Indexed as

AgingBrainCognitionDNA DamageE2F1 Transcription FactorEndothelial CellsAnimalsBlood-Brain BarrierCells, CulturedMaleMiceMice, Inbred C57BLOxidative StressE2f1 protein, mouseE2F1 Transcription FactoragingcognitionDNA damageE2F1endothelial cellsitaconate

Identifiers

PMID40761766
PMCPMC12321429

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.