Evidence map›Paper›PMID 40761710›Full record

ArticleMetabolism open2025

Quantitative lipidomic analysis reveals distinct metabolic traits between stromal cell subpopulations in human orbital adipose tissue.

Shuwei Tian, Xiaoli Zhang, Jiayong Yu, Juan Cai, Danni Wei, Siqi Li, Pengfei Cai, Wei Song, Suihan Feng, Mengle Shao and 1 more

Abstract read
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In one paragraph

Article in Metabolism open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Shuwei TianDepartment of Ophthalmology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
Xiaoli ZhangShanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, China.
Jiayong YuShanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, China.
Juan CaiShanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, China.
Danni WeiShanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, China.
Siqi LiShanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, China.
Pengfei CaiShanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, China.
Wei SongDepartment of Plastic Surgery, Yixing Medical Cosmetology Hospital of Xi'an, Xi'an, China.
Suihan FengState Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, China.
Mengle ShaoState Key Laboratory of Immune Response and Immunotherapy, Shanghai Institute of Immunity and Infection, Chinese Academy of Sciences, Shanghai, China.
Haizhou LiDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200011, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adipose tissue, a pivotal metabolic regulator, houses diverse stromal cell populations influencing its dynamic functions. Recent omics studies, including transcriptomics and proteomics, have revealed intricate cellular heterogeneity, yet comprehensive metabolic profiling remains limited. Leveraging fluorescence-activated cell sorting (FACS), we isolated PDGFRα+ DPP4+ and PDGFRα+ DPP4- adipose stromal cells (ASCs) from human orbital adipose tissue (OAT). Integrating gene expression analysis, in vitro adipogenesis assays, and quantitative lipidomics, we characterized their functional and metabolic distinctions. DPP4- ASCs exhibited enhanced adipogenic potential and distinct lipidomic profiles, featuring elevated ceramides and triacylglycerols compared to DPP4+ ASCs. Differential gene expression highlighted metabolic and adipogenic gene signatures reflective of their functional roles in adipose tissue remodeling. Our findings underscore the metabolic heterogeneity within OAT stromal fibroblasts, implicating DPP4- ASCs as potent regulators of adipogenesis and metabolic homeostasis. These insights enhance our understanding of adipose tissue plasticity and may inform therapeutic strategies for conditions like thyroid-associated ophthalmopathy.

Indexed as

Adipocyte precursor cellAdipose stromal cellMetabolic heterogeneityOrbital adipose tissueQuantitative lipidomics

Identifiers

PMID40761710
PMCPMC12320172

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.