ArticleGastro hep advances2025
Clinical and Genetic Profile of Pediatric and Adult Wilson's Disease in India.
Article in Gastro hep advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- [Research progress of inherited liver disease in 2025].Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology · 2026Review
- Molecular Characterization of Wilson's Disease in Liver Transplant Patients: A Five-Year Single-Center Experience in Iran.Diagnostics (Basel, Switzerland) · 2025Article
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19 authors.
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Abstract
Background and Aims: Wilson's disease (WD) is a disorder of copper metabolism caused by a mutation in the Methods: This was a single-center retrospective study conducted at AIG Hospitals, Hyderabad, India. Patients diagnosed and treated for WD both in outpatient and inpatient settings from June 2020 to April 2024 were included. Results: A total of 156 patients (women being 33.3%) with a median age of 19 years (2-57) were included from June 2020 to April 2024. Forty eight percent (n = 75) patients were of pediatric age <19 years. Clinical presentation with liver disease in the pediatric population included 26.7% with acute liver failure and 20% as acute-on-chronic liver failure compared to 30.9% with decompensated cirrhosis in the adults. On Kaplan-Meier analysis, in the pediatric group, the transplant-free survival was 72% (95% confidence interval [CI], 60.4-81.8) compared to 87.7% (95% CI, 78.5-93.9) in the adult group ( Conclusion: Pediatric patients with WD present more often with an acute illness and have lower transplant-free survival compared to adults, with ATP7B mutations identified in over half of those tested, highlighting the need for early genetic evaluation and tailored management.
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