Evidence map›Paper›PMID 40761652›Full record

ArticleERJ open research2025

Infant respiratory outcomes following asthma management and exacerbations in pregnancy.

Bronwyn K Brew, Peter G Gibson, Adam M Collison, Joerg Mattes, Gabriela Martins Costa Gomes, Annelies Robijn, Megan E Jensen, Wilfried Karmaus, Paul Robinson, Michael J Peek and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Bronwyn K BrewSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.ORCID https://orcid.org/0000-0002-9885-8261
Peter G GibsonSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.ORCID https://orcid.org/0000-0001-5865-489X
Adam M CollisonSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.
Joerg MattesSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.
Gabriela Martins Costa GomesSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.ORCID https://orcid.org/0000-0002-9807-7211
Annelies RobijnSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.ORCID https://orcid.org/0000-0001-5577-1118
Megan E JensenSchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.
Wilfried KarmausSchool of Public Health, University of Memphis, Memphis, TN, USA.ORCID https://orcid.org/0000-0003-2684-1492
Paul RobinsonChild Health Research Centre, The University of Queensland, Brisbane, QLD, Australia.ORCID https://orcid.org/0000-0001-7397-105X
Michael J PeekNepean Clinical School, Faculty of Medicine and Health, University of Sydney, Kingswood, NSW, Australia.
Sean SeehoReproduction and Perinatal Centre - Northern Precinct, Faculty of Medicine and Health, The University of Sydney, St Leonards, NSW, Australia.
Peter D SlyChild Health Research Centre, The University of Queensland, Brisbane, QLD, Australia.
Vanessa E MurphySchool of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia.ORCID https://orcid.org/0000-0003-3282-1324

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Improved maternal asthma management in pregnancy may reduce recurrent bronchiolitis and wheeze outcomes in infancy. We assessed whether infant bronchiolitis and wheeze outcomes are influenced by inflammation-guided management intervention, inhaled corticosteroid (ICS) use or exacerbations in pregnancy. Methods: A randomised controlled trial (RCT) secondary analysis and observational cohort analysis using the same study population was carried out. Pregnant women (12-23 weeks' gestation) from six centres in Australia were recruited and randomised to inflammation-guided asthma management or usual care between 2013 and 2023. ICS use and asthma exacerbations were reported during pregnancy and postnatally. When infants were 6 (n=691) and 12 (n=606) months of age, respiratory information was collected from parents and medical records. Associations for the RCT and observational analyses were assessed with logistic regression. Results: Guided asthma management in pregnancy was not associated with bronchiolitis or wheeze-related outcomes, for example for recurrent bronchiolitis at 12 months, the intervention OR was 1.04 (95% CI 0.62-1.73). In the observational analyses, ICS use in pregnancy was not associated with respiratory outcomes; however, asthma exacerbations in pregnancy were associated with at least one bronchiolitis episode (adjusted odds ratio (adjOR) 2.20, 95% CI 1.28-3.76) or croup episode (adjOR 4.34, 95% CI 1.89-9.96) at 6 months, and wheeze (adjOR 1.80, 95% CI 1.14-2.84) and increasing wheeze episodes at 12 months (adjOR 1.81, 95% CI 1.17-2.79). Conclusion: Although there was no evidence that guided asthma management or ICS use in pregnancy reduces infant bronchiolitis or wheeze, maternal asthma exacerbations are an important risk factor for these outcomes. Further research is needed to reduce exacerbations in pregnancy.

Identifiers

PMID40761652
PMCPMC12320104

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.