ArticleFrontiers in neurology2025
Brain metabolic changes associated with post-stroke pathological laughing and crying: an
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Pathological laughing and crying (PLC) is characterized by sudden, uncontrollable, and inappropriate episodes of laughter or crying. While previous studies have identified PLC-associated structural lesions, the underlying metabolic alterations in these patients remain unclear. Objective: We aimed to investigate cerebral metabolic alterations in patients with PLC following pontine stroke using Methods: In this retrospective study, we included 49 patients with pontine stroke admitted to a tertiary inpatient rehabilitation hospital between January 2011 and December 2021. Patients were classified into PLC ( Results: Compared with that of the non-PLC group, the PLC group exhibited significant hypometabolism in the right superior frontal gyrus ( Conclusion: Our findings reveal that PLC following pontine stroke is associated with distinct patterns of hypometabolism, particularly in the right superior frontal gyrus and the right inferior and middle temporal gyri. These regions may contribute to the regulation of emotional expression and provide insights into the neural mechanisms underlying PLC.
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