Evidence map›Paper›PMID 40761610›Full record

ArticleFrontiers in medical technology2025

New insights in fluid monitoring for surgical patients. A concept study.

Audrius Andrijauskas, Povilas Andrijauskas, Darius Dilijonas, Tomas Jovaiša, Vaidotas Marozas, Edgaras Stankevičius, Axel Kerroum, Darius Čincikas, Saulė Švedienė, Giedrius Kvederas and 2 more

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Article in Frontiers in medical technology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Audrius AndrijauskasClinic of Anesthesiology and Intensive Care, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Povilas AndrijauskasII Department of Anesthesiology and Intensive Care, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.
Darius DilijonasInstitute of Social Sciences and Applied Informatics, Kaunas Faculty, Vilnius University, Kaunas, Lithuania.
Tomas JovaišaClinic of Anesthesiology and Intensive Care, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Vaidotas MarozasFaculty of Electrical and Electronics Engineering, Kaunas University of Technology, Kaunas, Lithuania.
Edgaras StankevičiusInstitute of Physiology and Pharmacology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
Axel KerroumDepartment of Anesthesiology, Lausanne University Hospital, Lausanne, Switzerland.
Darius ČincikasClinic of Anesthesiology and Intensive Care, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Saulė ŠvedienėClinic of Anesthesiology and Intensive Care, Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Giedrius KvederasClinic of Rheumatology, Traumatology Orthopaedics and Reconstructive Surgery, Institute of ClinicalMedicine of the Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Narūnas PorvaneckasClinic of Rheumatology, Traumatology Orthopaedics and Reconstructive Surgery, Institute of ClinicalMedicine of the Faculty of Medicine, Vilnius University, Vilnius, Lithuania.
Christer SvensenKarolinska Institutet, Department of Science and Ediucation, Section of Anesthesia and Intensive Care, Södersjukhuset, Stockholm, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: This study evaluates the primary hypothesis of red cell mass (RCM) dependent amplitude of homeostatically acceptable limits of fluctuation in plasma dilution by exploring the correlation between RCM-specific equilibrated hematocrit (EQ_Hct) and amplitude of plasma dilution during perioperative mini Volume Loading Test (mVLT). Materials and methods: We retrospectively analyzed data from our previous RCTs, including 1,651 invasive arterial plasma dilution (aPD), 1,645 noninvasive "capillary" plasma dilution (cPD) and 236 estimates of EQ_Hct from 236 perioperative mVLT sessions. The cPD was estimated using noninvasive hemoglobin (SpHb, Masimo Radical 7, Irvine, CA) measurement. Fixed number of crystalloid boluses was used in 36 and 48 elective total knee arthroplasty (TKA) patients, and individualized number of boluses in 34 total hip arthroplasty (THA) patients for whom the number of boluses depended on the advices by our prototype automated clinical decision support system (ACDSS). Results: The primary hypothesis was confirmed-aPD decreased as EQ_Hct decreased when EQ_Hct <40%, and a very weak positive correlation was found between EQ_Hct and absolute aPD (Spearman's correlation coefficient 0.1025, Conclusion: This study points to the feasibility of Photoplethysmography (PPG) based estimates of hemoglobin concentration for continuous noninvasive monitoring of fluid accumulation and detecting imminent edema using the Homeostatic Blood States (HBS) theory and transcapillary reflux model. The ACDSS-guided fluid loading has a potential to minimise unnecessary fluid accumulation. Further research is needed to explore and improve these techniques.

Indexed as

hematocrithemodilutionhemoglobinhydrationinnovative techniqueperioperative fluid therapyplasma dilutiontranscapillary reflux

Identifiers

PMID40761610
PMCPMC12318955

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.