ArticleHealth science reports2025
Identification of Cuproptosis-Related Gene Clusters in Behçet's Disease and Its Immunological Profiles by Bioinformatics Analysis.
Article in Health science reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- From copper imbalance to immunometabolic remodeling: cuproptosis-related vulnerability and therapeutic hypotheses in autoimmune diseases.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026Review
- Cuproptosis: Biomarkers, Mechanisms and Treatments in Diseases.Molecules (Basel, Switzerland) · 2026Review
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Authors and funding
8 authors.
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Abstract
Background and Aims: Behçet's disease (BD) is a chronic inflammatory vasculitis marked by immune cell abnormalities and clinical variability. The recently discovered type of programmed cell death, termed cuproptosis, appears to be involved in multiple disease mechanisms. Thus, this study aimed to elucidate the involvement of cuproptosis-related genes (CRGs) in BD. Methods: We obtained two bipolar disorder datasets from the gene expression omnibus repository and pinpointed differentially expressed genes linked to cuproptosis (CuDEGs) from a selection of 52 CRGs. Subsequently, machine learning methods were employed to identify hub CuDEGs. We analyzed 44 BD specimens to identify two unique subgroups derived from these hub CuDEGs. Additionally, we conducted gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes pathway enrichment studies, along with gene set enrichment analysis (GSEA) and gene set variation analysis (GSVA), and assessed immune cell infiltration and immune function-related cells. Results: A total of 15 CuDEGs were discovered. Using machine learning algorithms, six hub CuDEGs were identified: Conclusion: This study demonstrates that CuDEGs are differentially expressed in BD and are associated with immune activity and pathway alterations. These findings suggest that cuproptosis may contribute to BD progression through the modulation of immune responses. Further experimental studies are needed to confirm these bioinformatics-based findings and explore their therapeutic potential.
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