ArticleJournal of multidisciplinary healthcare2025
Comparison of the Efficacy of Immune Checkpoint Inhibitors Combined with Chemotherapy Versus Bevacizumab Combined with Chemotherapy in Advanced Driver Gene-Negative Non-Squamous Non-Small Cell Lung Cancer: A Retrospective Study.
Article in Journal of multidisciplinary healthcare, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To compare the efficacy and safety of immune checkpoint inhibitors (ICIs) plus chemotherapy versus bevacizumab plus chemotherapy in advanced driver gene-negative non-squamous non-small cell lung cancer (NS-NSCLC). Methods: This retrospective cohort study included 199 patients treated from October 2015 to January 2022. Group A (n=103) received ICIs plus chemotherapy (pemetrexed + cisplatin), while Group B (n=96) received bevacizumab plus the same chemotherapy. Outcomes included treatment response, serum tumor markers (CEA, CA-125, CA-199), immunoglobulins (IgA, IgG, IgM), adverse reactions, and survival [progression-free survival (PFS), overall survival (OS)]. Results: Group A had a significantly higher objective response rate (59.22% vs 36.46%, P=0.001). Tumor marker levels decreased more in Group A (P<0.05), while declines in immunoglobulin levels were less pronounced (P<0.05). Adverse events were similar between groups (P>0.05). Group A had a longer median PFS (11.13 vs 7.37 months, P<0.05), and a non-significant trend toward longer OS (20.87 vs 18.4 months, P=0.159). Conclusion: ICIs combined with chemotherapy improved treatment efficacy and PFS compared to bevacizumab-based therapy in advanced driver gene-negative NS-NSCLC, with manageable safety and less impact on immune function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.