Evidence map›Paper›PMID 40761557›Full record

ArticleFrontiers in plant science2025

Transient expression of full-length and mature nattokinase in Nicotiana benthamiana reveals early necrosis from full-length form and functional activity of the mature enzyme.

Kevin Wang, Hugh Mason, Kylie Hall, Ethan Slone, Kylie Tackett, Nan Wang

Abstract read
In one paragraph

Article in Frontiers in plant science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kevin WangDivision of Math and Natural Sciences, University of Pikeville, Pikeville, KY, United States.
Hugh MasonSchool of Life Sciences, Arizona State University, Tempe, AZ, United States.
Kylie HallDivision of Math and Natural Sciences, University of Pikeville, Pikeville, KY, United States.
Ethan SloneDivision of Math and Natural Sciences, University of Pikeville, Pikeville, KY, United States.
Kylie TackettDivision of Math and Natural Sciences, University of Pikeville, Pikeville, KY, United States.
Nan WangBiotechnology Research Institute, Chinese Academy of Agriculture Sciences, Beijing, China.

Funding

WKU Lead Faculty AwardP20GM103436 · NIGMS · UNIVERSITY OF LOUISVILLE · PI ERIC C ROUCHKA · 2012 to 2026
$60.1M
NIGMS NIH HHS P20 GM103436
6 · The paper itself

Abstract

Nattokinase is a potent fibrinolytic enzyme widely used in the treatment of cardiovascular diseases for its ability to directly degrade fibrin and plasmin substrates, effectively dissolving blood clots. In this study, both full-length and mature forms of the nattokinase coding sequence were transiently expressed in

Indexed as

BEYDVcodon optimizationnattokinaseNicotiana benthamianaplant transient expression

Identifiers

PMID40761557
PMCPMC12319036

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.